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Positive and Negative Signals in Mast Cell Activation
Univ Manchester, Div Musculoskeletal & Dermatol Sci, Fac Biol Med & Hlth, Manchester, Lancs, England..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Haematology. Karolinska Inst, Dept Med, Immunol & Allergy Unit, Stockholm, Sweden.;Karolinska Univ Hosp, Stockholm, Sweden.
Acad Sci Czech Republ, Inst Mol Genet, Dept Signal Transduct, Prague, Czech Republic..
INSERM, U1149, Ctr Rech Inflammat, Paris, France.;CNRS, ERL8252, Paris, France.;Univ Paris Diderot, Sorbonne Paris Cite, Fac Med, Site Xavier Bichat,Inflamex Lab Excellence, Paris, France..
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2017 (English)In: Trends in immunology, ISSN 1471-4906, E-ISSN 1471-4981, Vol. 38, no 9, 657-667 p.Article, review/survey (Refereed) Published
Abstract [en]

Mast cells are powerful immune modulators of the tissue microenvironment. Within seconds of activation, these cells release a variety of preformed biologically active products, followed by a wave of mediator synthesis and secretion. Increasing evidence suggests that an intricate network of inhibitory and activating receptors, specific signaling pathways, and adaptor proteins governs mast cell responsiveness to stimuli. Here, we discuss the biological and clinical relevance of negative and positive signaling modalities that control mast cell activation, with an emphasis on novel Fc epsilon RI regulators, immunoglobulin E (IgE)-independent pathways [e.g., Mas-related G protein-coupled receptor X2 (MRGPRX2)], tetraspanins, and the CD300 family of inhibitory and activating receptors.

Place, publisher, year, edition, pages
2017. Vol. 38, no 9, 657-667 p.
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Immunology in the medical area
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URN: urn:nbn:se:uu:diva-334993DOI: 10.1016/j.it.2017.01.008ISI: 000408362600006PubMedID: 000408362600006OAI: oai:DiVA.org:uu-334993DiVA: diva2:1161345
Available from: 2017-11-29 Created: 2017-11-29 Last updated: 2017-11-29Bibliographically approved

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Nilsson, Gunnar

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