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Estrogen Receptor alpha, a Sex-Dependent Predictor of Aggressiveness in Nonfunctioning Pituitary Adenomas: SSTR and Sex Hormone Receptor Distribution in NFPA
Oslo Univ Hosp, Sect Specialized Endocrinol, Dept Endocrinol, Rikshosp, Pb 4950 Nydalen, N-0424 Oslo, Norway.;Univ Oslo, Inst Clin Med, Fac Med, N-0316 Oslo, Norway.;OUS Rikshosp, Res Inst Internal Med, N-0424 Oslo, Norway..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical and experimental pathology. Oslo Univ Hosp, Dept Pathol, N-0372 Oslo, Norway..ORCID iD: 0000-0001-7376-7331
Univ Oslo, Inst Clin Med, Fac Med, N-0316 Oslo, Norway.;OUS Rikshosp, Res Inst Internal Med, N-0424 Oslo, Norway..
Univ Oslo, Dept Biostat, Oslo Ctr Biostat & Epidemiol, Inst Basic Med Sci, N-0317 Oslo, Norway..
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2017 (English)In: Journal of Clinical Endocrinology and Metabolism, ISSN 0021-972X, E-ISSN 1945-7197, Vol. 102, no 9, 3581-3590 p.Article in journal (Refereed) Published
Abstract [en]

Context: Nonfunctioning pituitary adenomas (NFPAs) are fairly common and require a multidisciplinary approach. Reliable markers of a clinically aggressive course are lacking. Medical treatment is not available, and transsphenoidal surgery is the preferred primary treatment. Objective: We aimed to characterize the somatostatin, estrogen, and progesterone receptor distribution for NFPAs and compare it with factors of tumor aggressiveness. Design: Tumor samples for immunohistochemistry (n = 145) and quantitative reverse transcription polymerase chain reaction (n = 106) analyses of somatostatin receptor (SSTR) 1, SSTR2, SSTR3, SSTR5, estrogen receptor alpha (ER alpha), and progesterone receptor (PR) were measured by immunoreactive score (IRS) andmessenger RNA relative quantity and retrospectively compared with variables of aggressiveness. Setting: All patients were operated at the same tertiary referral center. Participants: A total of 164 patients with NFPA and tumor tissue from the primary operation were included. Results: SSTR3 was expressed abundantly by immunohistochemistry in all NFPAs. The IRS of ER alpha correlated with that of SSTR2 in male patients only (males, P<0.001; females, P = 0.8). Low ER alpha level was linked to a higher reintervention rate (P = 0.001) and earlier reintervention (P = 0.004) in male patients only (females, P = 0.95 and P = 0.65, respectively). Absence of ER alpha together with age provided a good prediction model for reintervention in male patients with gonadotroph adenomas. Conclusions: SSTR3 is expressed abundantly in NFPAs and is therefore a possible target for medical treatment. Absence of ER alpha together with young age may predict tumor recurrence in groups of NFPAs. Further validation in systematic prospective studies is needed.

Place, publisher, year, edition, pages
Oxford University Press, 2017. Vol. 102, no 9, 3581-3590 p.
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Endocrinology and Diabetes
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URN: urn:nbn:se:uu:diva-335636DOI: 10.1210/jc.2017-00792ISI: 000409352800061PubMedID: 28911153OAI: oai:DiVA.org:uu-335636DiVA: diva2:1164525
Available from: 2017-12-11 Created: 2017-12-11 Last updated: 2017-12-11Bibliographically approved

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Casar Borota, Olivera

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