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The effect of drinking water contaminated with perfluoroalkyl substances on a 10-year longitudinal trend of plasma levels in an elderly Uppsala cohort
MTM Research Centre, School of Science and Technology, Örebro University, 70182 Örebro, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Occupational and Environmental Medicine. (Magnus Svartengren)ORCID iD: 0000-0002-8949-3555
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.ORCID iD: 0000-0003-2335-8542
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2017 (English)In: Environmental Research, ISSN 0013-9351, E-ISSN 1096-0953, Vol. 159, p. 95-102, article id S0013-9351(17)30897-6Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: In 2012, drinking water contaminated with per- and polyfluoroalkyl substances (PFASs), foremost perfluorooctanesulfonic acid (PFOS) and perfluorohexanesulfonic acid (PFHxS) at levels over 20ng/L and 40ng/L, respectively, was confirmed in Uppsala, Sweden.

OBJECTIVES: We assessed how a longitudinally sampled cohort's temporal trend in PFAS plasma concentration was influenced by their residential location and determined the plausible association or disparity between the PFASs detected in the drinking water and the trend in the study cohort.

METHODS: The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) cohort provided plasma samples three times from 2001 to 2014. Individuals maintaining the same zip code throughout the study (n = 399) were divided into a reference (no known PFAS exposure), low, intermediate and high exposure area depending on the proportion of contaminated drinking water received. Eight PFASs detected in the majority (75%) of the cohort's plasma samples were evaluated for significant changes in temporal PFAS concentrations using a random effects (mixed) model.

RESULTS: PFHxS plasma concentrations continued to significantly increase in individuals living in areas receiving the largest percentage of contaminated drinking water (p < 0.0001), while PFOS showed an overall decrease. The temporal trend of other PFAS plasma concentrations did not show an association to the quality of drinking water received.

CONCLUSIONS: The distribution of contaminated drinking water had a direct effect on the trend in PFHxS plasma levels among the different exposure groups, resulting in increased concentrations over time, especially in the intermediate and high exposure areas. PFOS and the remaining PFASs did not show the same relationship, suggesting other sources of exposure influenced these PFAS plasma trends.

Place, publisher, year, edition, pages
2017. Vol. 159, p. 95-102, article id S0013-9351(17)30897-6
Keywords [en]
Drinking water, Longitudinal trend, PIVUS cohort, Perfluoroalkyl substances, Perfluorohexane sulfonic acid
National Category
Occupational Health and Environmental Health Environmental Sciences
Identifiers
URN: urn:nbn:se:uu:diva-336130DOI: 10.1016/j.envres.2017.07.050ISI: 000413280500011PubMedID: 28780137OAI: oai:DiVA.org:uu-336130DiVA, id: diva2:1165073
Funder
Swedish Research Council, K2009-64X-21031-01-3Swedish Research Council Formas, 216-2007-2047Available from: 2017-12-12 Created: 2017-12-12 Last updated: 2018-02-02Bibliographically approved

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Salihovic, SamiraLind, P. MonicaLind, LarsDunder, LindaSvartengren, Magnus

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