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Atypical anorexia nervosa is not related to brain structural changes in newly diagnosed adolescent patients.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Pediatric Endocrinology.
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2018 (English)In: International Journal of Eating Disorders, ISSN 0276-3478, E-ISSN 1098-108X, Vol. 51, no 1, p. 39-45Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: Patients with atypical anorexia nervosa (AN) have many features overlapping with AN in terms of genetic risk, age of onset, psychopathology and prognosis of outcome, although the weight loss may not be a core factor. While brain structural alterations have been reported in AN, there are currently no data regarding atypical AN patients.

METHOD: We investigated brain structure through a voxel-based morphometry analysis in 22 adolescent females newly-diagnosed with atypical AN, and 38 age- and sex-matched healthy controls (HC). ED-related psychopathology, impulsiveness and obsessive-compulsive traits were assessed with the Eating Disorder Examination Questionnaire (EDE-Q), Barratt Impulsiveness Scale (BIS-11) and Obsessive-compulsive Inventory Revised (OCI-R), respectively. Body mass index (BMI) was also calculated.

RESULTS: Patients and HC differed significantly on BMI (p < .002), EDE-Q total score (p < .000) and OCI-R total score (p < .000). No differences could be detected in grey matter (GM) regional volume between groups.

DISCUSSION: The ED-related cognitions in atypical AN patients would suggest that atypical AN and AN could be part of the same spectrum of restrictive-ED. However, contrary to previous reports in AN, our atypical AN patients did not show any GM volume reduction. The different degree of weight loss might play a role in determining such discrepancy. Alternatively, the preservation of GM volume might indeed differentiate atypical AN from AN.

Place, publisher, year, edition, pages
2018. Vol. 51, no 1, p. 39-45
Keywords [en]
MRI, OSFED, VBM, adolescent, anorexia, eating disorders, imaging
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-336179DOI: 10.1002/eat.22805ISI: 000418270800005PubMedID: 29215777OAI: oai:DiVA.org:uu-336179DiVA, id: diva2:1165191
Funder
Swedish Research Council FormasSwedish Research CouncilThe Swedish Brain FoundationAvailable from: 2017-12-12 Created: 2017-12-12 Last updated: 2018-02-19Bibliographically approved

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Olivo, GaiaSwenne, IngemarSalonen-Ros, HelenaLarsson, Elna-MarieGaudio, SantinoSchiöth, Helgi B.

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Olivo, GaiaSwenne, IngemarSalonen-Ros, HelenaLarsson, Elna-MarieGaudio, SantinoSchiöth, Helgi B.
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Functional PharmacologyPediatric EndocrinologyChild and Adolescent PsychiatryRadiology
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