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The impact of gut hormones on the neural circuit of appetite and satiety: A systematic review.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology.
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2017 (English)In: Neuroscience and Biobehavioral Reviews, ISSN 0149-7634, E-ISSN 1873-7528, Vol. 80, 457-475 p., S0149-7634(17)30138-0Article in journal (Refereed) Published
Abstract [en]

The brain-gut-axis is an interdependent system affecting neural functions and controlling our eating behaviour. In recent decades, neuroimaging techniques have facilitated its investigation. We systematically looked into functional and neurochemical brain imaging studies investigating how key molecules such as ghrelin, glucagon-like peptide-1 (GLP-1), peptide tyrosine-tyrosine (PYY), cholecystokinin (CCK), leptin, glucose and insulin influence the function of brain regions regulating appetite and satiety. Of the 349 studies published before July 2016 identified in the database search, 40 were included (27 on healthy and 13 on obese subjects). Our systematic review suggests that the plasma level of ghrelin, the gut hormone promoting appetite, is positively correlated with activation in the pre-frontal cortex (PFC), amygdala and insula and negatively correlated with activation in subcortical areas such as the hypothalamus. In contrast, the plasma levels of glucose, insulin, leptin, PYY, GLP-1 affect the same brain regions conversely. Our study integrates previous investigations of the gut-brain matrix during food-intake and homeostatic regulation and may be of use for future meta-analyses of brain-gut interactions.

Place, publisher, year, edition, pages
2017. Vol. 80, 457-475 p., S0149-7634(17)30138-0
Keyword [en]
Brain, GLP-1, Ghrelin, Glucose, Gut, Insulin, Leptin, PYY, fMRI
National Category
Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-336184DOI: 10.1016/j.neubiorev.2017.06.013PubMedID: 28669754OAI: oai:DiVA.org:uu-336184DiVA: diva2:1165201
Available from: 2017-12-12 Created: 2017-12-12 Last updated: 2017-12-12

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