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Height, selected genetic markers and prostate cancer risk: results from the PRACTICAL consortium.
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2017 (English)In: British Journal of Cancer, ISSN 0007-0920, E-ISSN 1532-1827, Vol. 117, no 5, 734-743 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Evidence on height and prostate cancer risk is mixed, however, recent studies with large data sets support a possible role for its association with the risk of aggressive prostate cancer.

METHODS: We analysed data from the PRACTICAL consortium consisting of 6207 prostate cancer cases and 6016 controls and a subset of high grade cases (2480 cases). We explored height, polymorphisms in genes related to growth processes as main effects and their possible interactions.

RESULTS: The results suggest that height is associated with high-grade prostate cancer risk. Men with height >180 cm are at a 22% increased risk as compared to men with height <173 cm (OR 1.22, 95% CI 1.01-1.48). Genetic variants in the growth pathway gene showed an association with prostate cancer risk. The aggregate scores of the selected variants identified a significantly increased risk of overall prostate cancer and high-grade prostate cancer by 13% and 15%, respectively, in the highest score group as compared to lowest score group.

CONCLUSIONS: There was no evidence of gene-environment interaction between height and the selected candidate SNPs.Our findings suggest a role of height in high-grade prostate cancer. The effect of genetic variants in the genes related to growth is seen in all cases and high-grade prostate cancer. There is no interaction between these two exposures.

Place, publisher, year, edition, pages
2017. Vol. 117, no 5, 734-743 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-336237DOI: 10.1038/bjc.2017.231PubMedID: 28765617OAI: oai:DiVA.org:uu-336237DiVA: diva2:1165428
Note

Pär Stattin, Instituionen för kirurgiska vetenskaper, urologkirurgi, är en av 69 collaborators. 

Available from: 2017-12-13 Created: 2017-12-13 Last updated: 2017-12-13

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