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Association between type 2 diabetes, curative treatment and survival in men with intermediate- and high-risk localized prostate cancer.
Kings Coll London, Div Canc Studies, Canc Epidemiol Grp, London, England.
Kings Coll London, Div Canc Studies, Canc Epidemiol Grp, London, England.
Guys & St Thomas NHS Fdn Trust, London, England.; Kings Coll Londons, Comprehens Biomed Res Ctr, London, England. .
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Urology. Umea Univ, Dept Surg & Peri Operat Sci Urol & Androl, Umea, Sweden.ORCID iD: 0000-0002-8306-0687
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2018 (English)In: BJU International, ISSN 1464-4096, E-ISSN 1464-410X, Vol. 121, no 2, p. 209-216Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To investigate whether curative prostate cancer (PCa) treatment was received less often by men with both PCa and Type 2 diabetes mellitus (T2DM) as little is known about the influence of T2DM diagnosis on the receipt of such treatment in men with localized PCa.

SUBJECTS AND METHODS: The Prostate Cancer database Sweden (PCBaSe) was used to obtain data on men with T2DM and PCa (n = 2210) for comparison with data on men with PCa only (n = 23 071). All men had intermediate- (T1-2, Gleason score 7 and/or prostate-specific antigen [PSA] 10-20 ng/mL) or high-risk (T3 and/or Gleason score 8-10 and/or PSA 20-50 ng/mL) localized PCa diagnosed between 1 January 2006 and 31 December 2014. Multivariate logistic regression was used to calculate the odds ratios (ORs) for receipt of curative treatment in men with and without T2DM. Overall survival, for up to 8 years of follow-up, was calculated both for men with T2DM only and for men with T2DM and PCa.

RESULTS: Men with T2DM were less likely to receive curative treatment for PCa than men without T2DM (OR 0.78, 95% confidence interval 0.69-0.87). The 8-year overall survival rates were 79% and 33% for men with T2DM and high-risk PCa who did and did not receive curative treatment, respectively.

CONCLUSIONS: Men with T2DM were less likely to receive curative treatment for localized intermediate- and high-risk PCa. Men with T2DM and high-risk PCa who received curative treatment had substantially higher survival times than those who did not. Some of the survival differences represent a selection bias, whereby the healthiest patients received curative treatment. Clinicians should interpret this data carefully and ensure that individual patients with T2DM and PCa are not under- nor overtreated.

Place, publisher, year, edition, pages
2018. Vol. 121, no 2, p. 209-216
Keywords [en]
#PCSM, #ProstateCancer, curative treatment, diabetes, external beam radiotherapy, prostatectomy
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-336246DOI: 10.1111/bju.13880ISI: 000424029800012PubMedID: 28418195OAI: oai:DiVA.org:uu-336246DiVA, id: diva2:1165447
Funder
Swedish Research Council, 825-2012-5047Stockholm County CouncilForte, Swedish Research Council for Health, Working Life and WelfareVästerbotten County CouncilAvailable from: 2017-12-13 Created: 2017-12-13 Last updated: 2018-11-16Bibliographically approved

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Stattin, PärZethelius, Björn

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