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International variations and trends in the treatment for retinopathy of prematurity
Univ Otago, Dept Paediat, Australia & New Zealand Neonatal Network, Christchurch, New Zealand..
Univ New South Wales, Australian & New Zealand Neonatal Network, Royal Hosp Women, Natl Perinatal Epidemiol & Stat Unit, Randwick, NSW, Australia..
Tokyo Womens Med Univ, Maternal & Perinatal Ctr, Neonatal Res Network Japan, Shinjuku Ku, Tokyo, Japan..
Sheba Med Ctr, Israel Neonatal Network, Gertner Inst Epidemiol & Hlth Policy Res, Tel Hashomer, Israel..
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2017 (English)In: British Journal of Ophthalmology, ISSN 0007-1161, E-ISSN 1468-2079, Vol. 101, no 10, p. 1399-1404Article in journal (Refereed) Published
Abstract [en]

Objective: To compare the rates of retinopathy of prematurity (ROP) and treatment of ROP by laser or intravitreal anti-vascular endothelial growth factor among preterm neonates from high-income countries participating in the International Network for Evaluating Outcomes (iNeo) of neonates.

Methods: A retrospective cohort study was conducted on extremely preterm infants weighing <1500 g at 24(0) to 27(6) weeks' gestation who were admitted to neonatal units in Australia/New Zealand, Canada, Finland, Israel, Japan, Spain, Sweden, Switzerland, Tuscany (Italy) and the UK between 2007 and 2013. Pairwise comparisons of ROP treatment in survivors between countries were evaluated by Poisson and multivariable logistic regression analyses after adjustment for confounders. A composite outcome of death or ROP treatment was compared between countries using logistic regression and standardised ratios.

Results: Of 48 087 infants included in the analysis, 81.8% survived to 32 weeks postmenstrual age, and 95% of survivors were screened for ROP. Rates of any ROP ranged from 25.2% to 91.0% in Switzerland and Japan, respectively, among those examined. The overall rate of those receiving treatment was 24.9%, which varied from 4.3% to 30.4%. Adjusted risk ratios for ROP treatment were lower for Switzerland in all pairwise comparisons, whereas Japan displayed significantly higher ratios. Comparisons of the composite outcome between countries revealed similar, but less marked differences.

Conclusions: Rates of any ROP and ROP treatment varied significantly between iNeo members, while an overall decline in ROP treatment was observed during the study period. It is unclear whether these variations represent differences in care practices, diagnosis and/or treatment thresholds.

Place, publisher, year, edition, pages
BMJ PUBLISHING GROUP , 2017. Vol. 101, no 10, p. 1399-1404
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-336438DOI: 10.1136/bjophthalmol-2016-310041ISI: 000411681700019PubMedID: 28270489OAI: oai:DiVA.org:uu-336438DiVA, id: diva2:1166022
Available from: 2017-12-14 Created: 2017-12-14 Last updated: 2017-12-14Bibliographically approved

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