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Cobalt Catalyzed, Regioselective C(sp(2))-H Activation of Amides with 1,3-Diynes
Linnaeus Univ, Dept Chem & Biomed Sci, Bioorgan & Biophys Chem Lab, SE-39182 Kalmar, Sweden.;Linnaeus Univ, Ctr Biomat Chem, SE-39182 Kalmar, Sweden..
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC. Linnaeus Univ, Dept Chem & Biomed Sci, Bioorgan & Biophys Chem Lab, SE-39182 Kalmar, Sweden.;Linnaeus Univ, Ctr Biomat Chem, SE-39182 Kalmar, Sweden..ORCID iD: 0000-0002-0407-6542
2017 (English)In: Organic Letters, ISSN 1523-7060, E-ISSN 1523-7052, Vol. 19, no 18, 4758-4761 p.Article in journal (Refereed) Published
Abstract [en]

The development of a first row transition metal (cobalt)-based catalyst for the as yet unexplored CH activation-driven reaction of 1,3-diynes, themselves a functional class of interest in a range of application areas, to form isoquinolinonesan important structural motif in a number of biologically active substancesis presented. This versatile and inexpensive catalyst employs a covalently attached bidendate-directing group, 8-aminoquinoline. The template directs the CH activation and facilitates the synthesis of a wide range of alkynylated heterocycles under mild conditions and with excellent regioselectivity. This strategy provides a novel and efficient route to diverse heterocyclic frameworks as demonstrated by its late stage application in bisheterocycle syntheses.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2017. Vol. 19, no 18, 4758-4761 p.
National Category
Organic Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-336482DOI: 10.1021/acs.orglett.7b02119ISI: 000411304300014PubMedID: 28846427OAI: oai:DiVA.org:uu-336482DiVA: diva2:1166724
Available from: 2017-12-15 Created: 2017-12-15 Last updated: 2017-12-15Bibliographically approved

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Nicholls, Ian A.

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