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High-dose B-vitamin supplements and risk for age-related cataract: a population-based prospective study of men and women
Karolinska Inst, Inst Environm Med, Div Nutr Epidemiol, SE-17177 Stockholm, Sweden..
Karolinska Inst, Inst Environm Med, Div Nutr Epidemiol, SE-17177 Stockholm, Sweden.;Orebro Univ, Dept Ophthalmol, Sch Med Sci, SE-70182 Orebro, Sweden..
Karolinska Inst, Div Biostat, Inst Environm Med, SE-17177 Stockholm, Sweden..
Karolinska Inst, Div Biochem Toxicol, Inst Environm Med, SE-17177 Stockholm, Sweden..
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2017 (English)In: British Journal of Nutrition, ISSN 0007-1145, E-ISSN 1475-2662, Vol. 118, no 2, 154-160 p.Article in journal (Refereed) Published
Abstract [en]

Previous studies that have investigated the association between B-vitamin supplement use and risk for cataract yield conflicting results. The aim of this study was to examine the association between use of high-dose B-vitamin supplements (approximately 10 times recommended daily intake) and risk for age-related cataract in a population-based prospective study of 13 757 women from the Swedish Mammography Cohort and 22 823 men from the Cohort of Swedish Men. Dietary supplement use and potential confounders were assessed using a questionnaire at baseline. Information on cataract diagnosis and extraction was obtained through linkage to registers. During the follow-up period between January 1998 and December 2011, we identified 8395 cataract cases (3851 for women and 4544 for men). The use of B vitamins plus other supplements and B vitamins only was associated with 9% (95% CI 2, 17) and 27% (95% CI 12, 43) increased risk for cataract, respectively. The hazard ratios for use of B vitamins only and risk for cataract stratified by different age groups were as follows: < 60 years: 1.88 (95% CI 1.47, 2.39); 60-69 years: 1.21 (95% CI 0.96, 1.53); and >= 70 years: 1.09 (95% CI 0.91, 1.31) (P-interaction=0.002). Our results suggest that the use of high-dose B-vitamin supplements was associated with an increased risk for cataract. This association might be confined to younger participants.

Place, publisher, year, edition, pages
CAMBRIDGE UNIV PRESS , 2017. Vol. 118, no 2, 154-160 p.
Keyword [en]
B-vitamin supplements, Cataracts, Prospective cohort studies, Nutritional epidemiology
National Category
Nutrition and Dietetics
Identifiers
URN: urn:nbn:se:uu:diva-335682DOI: 10.1017/S0007114517001994ISI: 000409508200007PubMedID: 28820082OAI: oai:DiVA.org:uu-335682DiVA: diva2:1168145
Available from: 2017-12-20 Created: 2017-12-20 Last updated: 2017-12-21Bibliographically approved

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