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Genome-wide association study identifies multiple risk loci for renal cell carcinoma.
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2017 (English)In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 8, article id 15724Article in journal (Refereed) Published
Abstract [en]

Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P=3.1 × 10-10), 3p22.1 (rs67311347, P=2.5 × 10-8), 3q26.2 (rs10936602, P=8.8 × 10-9), 8p21.3 (rs2241261, P=5.8 × 10-9), 10q24.33-q25.1 (rs11813268, P=3.9 × 10-8), 11q22.3 (rs74911261, P=2.1 × 10-10) and 14q24.2 (rs4903064, P=2.2 × 10-24). Expression quantitative trait analyses suggest plausible candidate genes at these regions that may contribute to RCC susceptibility.

Place, publisher, year, edition, pages
2017. Vol. 8, article id 15724
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-337238DOI: 10.1038/ncomms15724PubMedID: 28598434OAI: oai:DiVA.org:uu-337238DiVA, id: diva2:1168654
Available from: 2017-12-21 Created: 2017-12-21 Last updated: 2017-12-21

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