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Coffee Consumption and Risk of Gallbladder Cancer in a Prospective Study.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
2017 (English)In: Journal of the National Cancer Institute, ISSN 0027-8874, E-ISSN 1460-2105, Vol. 109, no 3, p. 1-3Article in journal (Refereed) Published
Abstract [en]

Evidence indicates that coffee consumption may reduce the risk of gallstone disease, which is strongly associated with increased risk of gallbladder cancer. The association between coffee consumption and gallbladder cancer incidence was examined in a prospective cohort study of 72 680 Swedish adults (aged 45 - 83 years) who were free of cancer and reported their coffee consumption at baseline. Gallbladder cancers were ascertained by linkage with the Swedish Cancer Register. The data were analyzed using Cox proportional hazards regression models. Statistical tests were two-sided. During 967 377 person-years of follow-up, 74 gallbladder cancer case patients were identified. Compared with consumption of one or less cups of coffee per day, the multivariable hazard ratios were 0.76 (95% confidence interval [CI] = 0.41 to 1.41) for two cups per day, 0.50 (95% CI = 0.24 to 1.06) for three cups per day, and 0.41 (95% CI = 0.20 to 0.83) for four or more cups per day. In conclusion, coffee consumption is associated with a reduced risk of gallbladder cancer.

Place, publisher, year, edition, pages
2017. Vol. 109, no 3, p. 1-3
National Category
Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-337257DOI: 10.1093/jnci/djw237PubMedID: 28376203OAI: oai:DiVA.org:uu-337257DiVA, id: diva2:1168692
Available from: 2017-12-21 Created: 2017-12-21 Last updated: 2017-12-21

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