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Normal values for calprotectin in stool samples of infants from the population-based longitudinal born into life study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab. Swedish Univ Agr Sci, Dept Forest Mycol & Plant Pathol, Sci Life Labs, Almas Alle 5, S-75007 Uppsala, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0003-2071-5866
Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden; Karolinska Univ Hosp, Astrid Lindgren Childrens Hosp, Unit Paediat Allergy & Pulmonol, Stockholm, Sweden.
Karolinska Inst, Danderyd Hosp, Div Obstet & Gynaecol, Dept Clin Sci, Stockholm, Sweden.
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2018 (English)In: Scandinavian Journal of Clinical and Laboratory Investigation, ISSN 0036-5513, E-ISSN 1502-7686, Vol. 78, no 1-2, p. 120-124Article in journal (Refereed) Published
Abstract [en]

Faecal calprotectin is a protein used as a diagnostic marker for inflammatory bowel diseases. We determined upper limits for normal calprotectin values for neonatal, 6, 12 and 24 months old children using a turbidimetric immunoassay in a cohort of Swedish children. The advantage of the method is that opposite to previously used enzyme-linked immunosorbent assay (ELISA) method, it enables measuring single samples, and thus, shortens the analysis time significantly. There were 72 samples (41.7% female) collected neonatally, 63 samples (34.9% female) at 6 months, 60 samples (40.0% female) at 12 months and 51 samples (43.1% female) at 24 months. The upper limits for normal values were 233, 615, 136 and 57 µg mg-1 for infants aged 0, 6, 12 and 24 months, respectively.

Place, publisher, year, edition, pages
Taylor & Francis Group, 2018. Vol. 78, no 1-2, p. 120-124
Keywords [en]
Calprotectin, abdominal pain, inflammatory bowel disease, normal values, turbidimetric immunoassay
National Category
Gastroenterology and Hepatology Clinical Laboratory Medicine
Identifiers
URN: urn:nbn:se:uu:diva-337523DOI: 10.1080/00365513.2017.1420216ISI: 000424952600019PubMedID: 29283308OAI: oai:DiVA.org:uu-337523DiVA, id: diva2:1169901
Funder
Swedish Research Council, 2015-03477 2010-15062-79050-11 2015-02434Stockholm County CouncilSwedish Heart Lung FoundationAvailable from: 2017-12-30 Created: 2017-12-30 Last updated: 2018-04-10Bibliographically approved

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Peura, SariFall, ToveHelmersson-Karlqvist, JohannaLarsson, Anders

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