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Transplantation of Macro-encapsulated Human Islets within the Bioartificial Pancreas β Air to Patients with Type 1 Diabetes Mellitus
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Transplantation and regenerative medicine.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Transplantation and regenerative medicine.ORCID iD: 0000-0001-8843-7941
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
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2018 (English)In: American Journal of Transplantation, ISSN 1600-6135, E-ISSN 1600-6143, Vol. 18, no 7, p. 1735-1744Article in journal (Refereed) Published
Abstract [en]

Macroencapsulation devices provide the dual possibility to immunoprotect transplanted cells while also being retrievable; the latter bearing importance for safety in future trials with stem-cell derived cells. However, macroencapsulation entails a problem with oxygen supply to the encapsulated cells. The βAir device solves this with an incorporated refillable oxygen tank. This phase 1 study evaluated the safety and efficacy of implanting the βAir device containing allogeneic human pancreatic islets to patients with type 1 diabetes. Four patients were transplanted with 1-2 βAir devices, each containing 155000-180000 IEQ (i.e. 1800-4600 IEQ per kg body weight), and monitored for 3-6 months, followed by the recovery of devices. Implantation of the βAir device was safe and successfully prevented immunization and rejection of the transplanted tissue. However, although beta cells survived in the device, only minute levels of circulating C-peptide were observed with no impact on metabolic control. Fibrotic tissue with immune cells was formed in capsule surroundings. Recovered devices displayed a blunted glucose-stimulated insulin response, and amyloid formation in the endocrine tissue. We conclude that the βAir device is safe and can support survival of allogeneic islets for several months, although the function of the transplanted cells was limited.

Place, publisher, year, edition, pages
2018. Vol. 18, no 7, p. 1735-1744
National Category
Endocrinology and Diabetes Surgery Immunology in the medical area
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URN: urn:nbn:se:uu:diva-337701DOI: 10.1111/ajt.14642PubMedID: 29288549OAI: oai:DiVA.org:uu-337701DiVA, id: diva2:1170569
Note

De två första författarna delar förstaförfattarskapet.

Available from: 2018-01-03 Created: 2018-01-03 Last updated: 2018-08-16Bibliographically approved

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Carlsson, Per-OlaEspes, DanielSedigh, AmirWestermark, GunillaCarlbom, LinaAhlström, HåkanEriksson, OlofOlerud, JohanKorsgren, Olle

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Carlsson, Per-OlaEspes, DanielSedigh, AmirWestermark, GunillaCarlbom, LinaAhlström, HåkanEriksson, OlofOlerud, JohanKorsgren, Olle
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Transplantation and regenerative medicineTransplantation SurgeryDepartment of Medical Cell BiologyRadiologyDepartment of Medicinal ChemistryClinical Immunology
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American Journal of Transplantation
Endocrinology and DiabetesSurgeryImmunology in the medical area

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