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Longitudinal uncoupling of cerebral perfusion, glucose metabolism, and tau deposition in Alzheimer's disease.
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2018 (English)In: Alzheimer's & Dementia, ISSN 1552-5260, E-ISSN 1552-5279, Vol. 14, no 5, p. 652-663Article in journal (Refereed) Published
Abstract [en]

INTRODUCTION: Cross-sectional findings using the tau tracer [18F]THK5317 (THK5317) have shown that [18F]fluorodeoxyglucose (FDG) positron emission tomography data can be approximated using perfusion measures (early-frame standardized uptake value ratio; ratio of tracer delivery in target to reference regions). In this way, a single positron emission tomography study can provide both functional and molecular information.

METHODS: We included 16 patients with Alzheimer's disease who completed follow-up THK5317 and FDG studies 17 months after baseline investigations. Linear mixed-effects models and annual percentage change maps were used to examine longitudinal change.

RESULTS: Limited spatial overlap was observed between areas showing declines in THK5317 perfusion measures and FDG. Minimal overlap was seen between areas showing functional change and those showing increased retention of THK5317.

DISCUSSION: Our findings suggest a spatiotemporal offset between functional changes and tau pathology and a partial uncoupling between perfusion and metabolism, possibly as a function of Alzheimer's disease severity.

Place, publisher, year, edition, pages
2018. Vol. 14, no 5, p. 652-663
Keywords [en]
Alzheimer's disease, Alzheimer's disease dementia, FDG, Hypometabolism, Longitudinal study, Mild cognitive impairment, Neurofibrillary tangles, Perfusion SUVR, Perfusion imaging, Positron emission tomography (PET), Prodromal Alzheimer's disease, R(1), THK5317, Tau imaging
National Category
Radiology, Nuclear Medicine and Medical Imaging Medicinal Chemistry Neurosciences
Identifiers
URN: urn:nbn:se:uu:diva-337704DOI: 10.1016/j.jalz.2017.11.008ISI: 000432438800009PubMedID: 29268078OAI: oai:DiVA.org:uu-337704DiVA, id: diva2:1170574
Funder
Swedish Research Council, 05817Swedish Foundation for Strategic Research Gun och Bertil Stohnes StiftelseThe Karolinska Institutet's Research FoundationThe Swedish Brain FoundationWenner-Gren FoundationsAvailable from: 2018-01-03 Created: 2018-01-03 Last updated: 2018-08-01Bibliographically approved

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Jonasson, MyLubberink, MarkWall, AndersAntoni, Gunnar

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Radiology, Nuclear Medicine and Medical ImagingMedicinal ChemistryNeurosciences

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