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Genomic signatures of 60 years of bidirectional selection for 8-week body weight in chickens
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. (Örjan Carlborg)ORCID iD: 0000-0001-8714-0812
Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, People’s Republic of China. (Carlborg)
Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden; Department of Veterinary Integrative Biosciences, Texas A&M University, College Station. (Leif Andersson)
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2017 (English)In: Poultry Science, ISSN 0032-5791, E-ISSN 1525-3171, Vol. 97, no 3, p. 781-790Article in journal (Refereed) Published
Abstract [en]

Sixty years, constituting 60 generations, have passed since the founding of the Virginia body weight lines, an experimental population of White Plymouth Rock chickens. Using a stringent breeding scheme for divergent 8-week body weight, the lines, which originated from a common founder population, have responded to bidirectional selection with an approximate 15-fold difference in the selected trait. They provide a model system to study the genetics of complex traits in general and the influences of artificial selection on quantitative genetic architectures in particular. As we reflect on the 60th anniversary of the initiation of the Virginia body weight lines, there is opportunity to discuss the findings obtained using different analytical and experimental genetic and genomic strategies and integrate them with a recent pooled genome resequencing dataset. Hundreds of regions across the genome show differentiation between the 2 lines, reinforcing previous findings that response to selection relied on standing variation across many genes and giving insights into the haplotype complexity underlying regions associated with body weight.

Place, publisher, year, edition, pages
2017. Vol. 97, no 3, p. 781-790
National Category
Genetics Bioinformatics (Computational Biology) Agricultural Science
Research subject
Genetics
Identifiers
URN: urn:nbn:se:uu:diva-337971DOI: 10.3382/ps/pex383ISI: 000426061600008OAI: oai:DiVA.org:uu-337971DiVA, id: diva2:1171216
Funder
Swedish National Infrastructure for Computing (SNIC), b2015010Swedish Research Council, 2012-4634Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning, 2010-643Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning, 2013-450Available from: 2018-01-06 Created: 2018-01-06 Last updated: 2018-05-09Bibliographically approved

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Lillie, MetteAndersson, LeifCarlborg, Örjan

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