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Inconsistent Reporting Between Meta-analysis Protocol and Publication – A Cross-Sectional Study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Plastic Surgery.ORCID iD: 0000-0001-9107-5814
Karolinska Institute, Department of Clinical Neuroscience.ORCID iD: 0000-0003-4389-5089
2017 (English)In: Anticancer Research, ISSN 0250-7005, E-ISSN 1791-7530, Vol. 37, no 9, p. 5101-5107Article in journal (Refereed) Published
Abstract [en]

Background: Inconsistent reporting in published meta-analyses compared to registered protocol are poorly understood. The aim of the study was to assess inconsistencies between registered protocols and published reports among oncology drug meta-analyses.

Materials and Methods: A cross-sectional study was performed including oncology drug meta-analyses published between January 1st and November 14th 2016 with a published protocol. Two investigators extracted data on: selection criteria, outcome(s) and statistical plan in protocol and manuscript, plus self-acknowledgement of inconsistent reporting between protocol and publication.

Results: Protocol registration was present in 19% (23/119) of all oncology drug meta-analyses. In meta-analyses with protocol (n= 23), 70% (16/23) had issues with inconsistent reporting between protocol and published report concerning; inclusion criteria, comparator group, intervention, outcome (PICO) or statistical analysis. Self-acknowledgement of changes between protocol and publication was found in 50% (8/16).

Conclusion: In meta-analyses with protocol, discrepancies between registered protocols and publications are frequent.

Place, publisher, year, edition, pages
2017. Vol. 37, no 9, p. 5101-5107
Keywords [en]
Meta-analysis protocol, inconsistent reporting, published report, trial registration
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-337764DOI: 10.21873/anticanres.11928ISI: 000412578200051PubMedID: 28870940OAI: oai:DiVA.org:uu-337764DiVA, id: diva2:1173537
Available from: 2018-01-12 Created: 2018-01-12 Last updated: 2018-01-12Bibliographically approved

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Falk Delgado, AlbertoFalk Delgado, Anna

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