Effects of pre-and postmenopausal use of exogenous hormones on receptor content in normal human breast tissue: A randomized study
2008 (English)In: Gynecological Endocrinology, ISSN 0951-3590, Vol. 24, no 8, 475-480 p.Article in journal (Refereed) Published
Objective. To examine the effects of exposure to endogenous and exogenous hormones on estrogen receptor- (ER) and progesterone receptor (PR) levels in normal human breast tissue. Methods. In a randomized study of women scheduled for mammary reduction plasty (n = 81), ER and PR content in breast parenchyma was analyzed in premenopausal (n = 49) and postmenopausal (n = 16) women. Premenopausal women were randomized to surgery in the follicular or luteal phase of the menstrual cycle or after oral contraceptive treatment for 2 months. Postmenopausal women were randomized to sequential or estrogen-only therapy for 2 months prior to surgery. Results. ER content was higher in parous than in nulliparous (p = 0.009) premenopausal women and displayed a positive association with age (rs = 0.51, p = 0.0002). Compared with premenopausal women in the follicular phase, postmenopausal women had higher ER content (p = 0.040) whereas premenopausal women on oral contraception had lower ER (p = 0.048) and PR (p = 0.007) content. Smokers had lower PR content than non-smokers (p = 0.02). Conclusion. In the present study ER content was higher in parous than in non-parous women and associated with premenopausal age. Short-term oral contraceptives yielded lower ER and PR contents. Postmenopausal estrogen/progestogen combined therapy yielded lower PR content than estrogen-only therapy.
Place, publisher, year, edition, pages
2008. Vol. 24, no 8, 475-480 p.
Estrogen receptor-a, human breast tissue, oral contraceptives, postmenopausal, progesterone receptor, premenopausal
IdentifiersURN: urn:nbn:se:uu:diva-86532DOI: 10.1080/09513590802234204ISI: 000260457200010OAI: oai:DiVA.org:uu-86532DiVA: diva2:117376