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The human protein atlas: A spatial map of the human proteome
KTH Royal Inst Technol, Sch Biotechnol, Sci Life Lab, SE-17121 Stockholm, Sweden..
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
2018 (English)In: Protein Science, ISSN 0961-8368, E-ISSN 1469-896X, Vol. 27, no 1, p. 233-244Article in journal (Refereed) Published
Abstract [en]

The correct spatial distribution of proteins is vital for their function and often mis-localization or ectopic expression leads to diseases. For more than a decade, the Human Protein Atlas (HPA) has constituted a valuable tool for researchers studying protein localization and expression in human tissues and cells. The centerpiece of the HPA is its unique antibody collection for mapping the entire human proteome by immunohistochemistry and immunocytochemistry. By these approaches, more than 10 million images showing protein expression patterns at a single-cell level were generated and are publicly available at . The antibody-based approach is combined with transcriptomics data for an overview of global expression profiles. The present article comprehensively describes the HPA database functions and how users can utilize it for their own research as well as discusses the future path of spatial proteomics.

Place, publisher, year, edition, pages
WILEY , 2018. Vol. 27, no 1, p. 233-244
Keywords [en]
spatial proteomics, transcriptomics, antibodies, immunohistochemistry, immunofluorescence, single-cell, protein expression
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-338967DOI: 10.1002/pro.3307ISI: 000418254300024PubMedID: 28940711OAI: oai:DiVA.org:uu-338967DiVA, id: diva2:1175651
Funder
Knut and Alice Wallenberg FoundationAvailable from: 2018-01-18 Created: 2018-01-18 Last updated: 2018-01-18Bibliographically approved

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Lindskog, Cecilia

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