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Does ovarian stimulation regimen affect IVF outcome?: a two-centre, real-world retrospective study using predominantly cleavage-stage, single embryo transfer
Karolinska Univ Hosp, Reprod Med Obstet & Gynecol, SE-14186 Stockholm, Sweden..
Carl von Linne Clin, SE-75183 Uppsala, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
Karolinska Univ Hosp, Reprod Med Obstet & Gynecol, SE-14186 Stockholm, Sweden.;Karolinska Inst, Dept Oncol Pathol, SE-17177 Stockholm, Sweden..
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2018 (English)In: Reproductive Biomedicine Online, ISSN 1472-6483, E-ISSN 1472-6491, Vol. 36, no 1, p. 59-66Article in journal (Refereed) Published
Abstract [en]

In this study, ovarian stimulation using highly purified human menopausal gonadotrophin (HP-HMG) and recombinant FSH (rFSH) for IVF were compared in two large assisted reproduction technique centres in Sweden. A total of 5902 women underwent 9631 oocyte retrievals leading to 8818 embryo transfers (7720 on day 2): single embryo transfers (74.2%); birth rate per embryo transfer (27.7%); multiple birth rate (5.0%); incidence of severe ovarian hyperstimulation syndrome (0.71%). Compared with ovarian stimulation with rFSH, women who received HP-HMG were older, had higher dosages of gonadotrophins administered, fewer oocytes retrieved and more embryos transferred. After multivariate analysis controlling for age and generalized estimating equation model, no differences were found in delivery outcomes per embryo transfers between HP-HMG and rFSH, independent of gonadotrophin releasing hormone analogue (GnRH) used. Logit curves for live birth rate suggested differences for various subgroups, most prominently for women with high oocyte yield or when high total doses were used. Differences were not significant, perhaps owing to skewed distributions of the FSH compounds versus age and other covariates. These 'real-life patients' had no differences in live birth rate between HP-HMG and rFSH overall or in subgroups of age, embryo score, ovarian sensitivity or use of GnRH analogue regimen.

Place, publisher, year, edition, pages
ELSEVIER SCI LTD , 2018. Vol. 36, no 1, p. 59-66
Keywords [en]
Controlled ovarian stimulation, Delivery rate, GnRH agonist/antagonist, HP-HMG, Recombinant FSH
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
URN: urn:nbn:se:uu:diva-338962DOI: 10.1016/j.rbmo.2017.10.102ISI: 000418895700009PubMedID: 29233501OAI: oai:DiVA.org:uu-338962DiVA, id: diva2:1175657
Available from: 2018-01-18 Created: 2018-01-18 Last updated: 2018-01-18Bibliographically approved

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Hadziosmanovic, Nermin

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