uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
11C-Acetylation of Amines with [11C]Methyl Iodide with Bis(cyclopentadienyldicarbonyliron) as the CO Source
Karolinska Institute, Stockholm, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
2017 (English)In: European Journal of Organic Chemistry, ISSN 1434-193X, E-ISSN 1099-0690, no 38, p. 5785-5788Article in journal (Refereed) Published
Abstract [en]

We describe herein a novel approach for the direct 11C-acetylation of amines. The carbonylative protocol is palladium-mediated, uses bis(cyclopentadienyldicarbonyliron) as the CO source, and [11C]methyl iodide or [11C]methyl iodide-D3 as a radioactive precursor. A set of functionalized primary and secondary amines was 11C-labelled in radiochemical yields ranging from 7–85 %. The potential use of this method for positron emission tomography radiotracer production was additionally demonstrated by the radiosynthesis of [11C]lacosamide, [11C]melatonine, and [11C]acecainide in 44–55 % RCY.

Place, publisher, year, edition, pages
2017. no 38, p. 5785-5788
Keywords [en]
Isotopic labeling, Acylation, Positron emission tomography, Palladium, Methyl iodide
National Category
Medicinal Chemistry Organic Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-339752DOI: 10.1002/ejoc.201701154ISI: 000413162300010OAI: oai:DiVA.org:uu-339752DiVA, id: diva2:1177457
Note

Title in WoS: C-11-Acetylation of Amines with [C-11]Methyl Iodide with Bis(cyclopentadienyldicarbonyliron) as the CO Source

Available from: 2018-01-25 Created: 2018-01-25 Last updated: 2018-02-21Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full text

Authority records BETA

Nordeman, Patrik

Search in DiVA

By author/editor
Nordeman, Patrik
By organisation
Organic Pharmaceutical Chemistry
In the same journal
European Journal of Organic Chemistry
Medicinal ChemistryOrganic Chemistry

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 12 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf