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Membrane interactions and antimicrobial effects of inorganic nanoparticles
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy. Univ Copenhagen, Dept Pharm, DK-2100 Copenhagen, Denmark..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy. Univ Copenhagen, Dept Pharm, DK-2100 Copenhagen, Denmark.;Uppsala Univ, Dept Pharm, POB 580, SE-75123 Uppsala, Sweden..ORCID iD: 0000-0003-0046-5599
2017 (English)In: Advances in Colloid and Interface Science, ISSN 0001-8686, E-ISSN 1873-3727, Vol. 248, p. 105-128Article in journal (Refereed) Published
Abstract [en]

Interactions between nanoparticles and biological membranes are attracting increasing attention in current nanomedicine, and play a key role both for nanotoxicology and for utilizing nanomaterials in diagnostics, drug delivery, functional biomaterials, as well as combinations of these, e.g., in theranostics. In addition, there is considerable current interest in the use of nanomaterials as antimicrobial agents, motivated by increasing resistance development against conventional antibiotics. Here, various nanomaterials offer opportunities for triggered functionalites to combat challenging infections. Although the performance in these diverse applications is governed by a complex interplay between the nanomaterial, the properties of included drugs (if any), and the biological system, nanoparticle-membrane interactions constitute a key initial step and play a key role for the subsequent biological response. In the present overview, the current understanding of inorganic nanomaterials as antimicrobial agents is outlined, with special focus on the interplay between antimicrobial effects and membrane interactions, and how membrane interactions and antimicrobial effects of such materials depend on nano particle properties, membrane composition, and external (e.g., light and magnetic) fields.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE BV , 2017. Vol. 248, p. 105-128
Keywords [en]
Antimicrobial, Lipid bilayer, Membrane, Nanomaterials
National Category
Basic Medicine
Identifiers
URN: urn:nbn:se:uu:diva-340149DOI: 10.1016/j.cis.2017.07.029ISI: 000413380700006PubMedID: 28807368OAI: oai:DiVA.org:uu-340149DiVA, id: diva2:1177863
Funder
Swedish Research Council, 2016-05157Available from: 2018-01-26 Created: 2018-01-26 Last updated: 2018-01-26Bibliographically approved

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Malekkhaiat Häffner, SaraMalmsten, M

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