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Nano-structural comparison of 2-methacryloyloxyethyl phosphorylcholine- and ethylene glycol-based surface modification for preventing protein and cell adhesion
Univ Tokyo, Dept Bioengn, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138656, Japan..
Shibaura Inst Technol, Dept Mat Sci & Engn, Coll Engn, Koto Ku, 3-7-5 Toyosu, Tokyo 1358548, Japan..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Univ Tokyo, Dept Bioengn, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138656, Japan..
Shibaura Inst Technol, Dept Mat Sci & Engn, Coll Engn, Koto Ku, 3-7-5 Toyosu, Tokyo 1358548, Japan..
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2017 (English)In: Colloids and Surfaces B: Biointerfaces, ISSN 0927-7765, E-ISSN 1873-4367, Vol. 159, p. 655-661Article in journal (Refereed) Published
Abstract [en]

Polymer brush, owing to its precisely controllable nanostructure, has great potential for surface modification in the biomedical field. In this study, we evaluated the bio-inertness of polymer brush, monomer monolayers, and polymer-coated surfaces based on their structures, to identify the most effective bio-inert modification. We focused on two well-known bio-inert materials, 2-methacryloyloxyethyl phosphorylcholine (MPC) and ethylene glycol (EG). The amount of adsorbed proteins on the surface was found to be dependent on the monomer unit density in the case of MPC, whereas this correlation was not observed in the case of EG. Cell adhesion was suppressed on the brush structure of both MPC and EG units, regardless of their density. The brush structure of MPC and EG units showed better anti-protein and anti-cell-adhesion than monolayers and polymer-coated surfaces. Thus, the steric repulsion was not only important in EG units-based surface, but also in MPC-based surface. In addition, multiple polymer layers formed by MPC-based polymer coating also displayed similar properties. (C) 2017 Elsevier B.V. All rights reserved.

Place, publisher, year, edition, pages
Elsevier, 2017. Vol. 159, p. 655-661
Keywords [en]
MPC polymer, PEG, Polymer brush, Polymer coating, Monolayer, Cell adhesion
National Category
Polymer Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-339698DOI: 10.1016/j.colsurfb.2017.08.039ISI: 000418729600076PubMedID: 28866413OAI: oai:DiVA.org:uu-339698DiVA, id: diva2:1178171
Available from: 2018-01-29 Created: 2018-01-29 Last updated: 2018-01-29Bibliographically approved

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Teramura, Yuji

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