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Selection strategies for newly registered blood donors in European countries
Sanquin Blood Supply Fdn, Dept Blood Borne Infect, Amsterdam, Netherlands..
European Ctr Dis Prevent & Control, Dept Surveillance & Response Support, Stockholm, Sweden..
Sanquin Blood Supply Fdn, Dept Donor Studies, Amsterdam, Netherlands..
Austrian Red Cross Blood Transfus Serv, Vienna, Austria..
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2017 (English)In: Blood Transfusion, ISSN 1723-2007, Vol. 15, no 6, p. 495-501Article in journal (Refereed) Published
Abstract [en]

Background: Two selection strategies for newly-registered blood donors are available: a singlevisit selection called the standard selection procedure (SSP), and a two-stage selection named predonation and donation screening (PDS). This study reviews the selection strategies for newly-registered donors currently applied in European countries.

Material and methods: We collected data on donor selection procedures, blood donation, laboratory screening and HIV, HCV and HBV positive donors/donations from 2010 to 2013 in 30 European countries by using questionnaires. We grouped the countries according to the applied selection strategy, and for each country, we calculated the 4-year prevalence of confirmed positive results indicating the presence of overall and recent HIV, HCV and HBV infections among first-time and repeat donations and among newly-registered donors.

Results: Most of the 24 countries (80%) apply the SSP strategy for selection of newly-registered donors. Twenty-two countries (73.3%) employ a nucleic acid amplification testing in addition to the mandatory serological screening. The survey confirms a higher overall prevalence of HIV, HCV and HBV infections among first-time donations and newly-registered donors than among repeat donations. In contrast, the prevalence of recently acquired HIV and HCV infections was lower among first-time donations and newly-registered donors than among repeat donations, but higher for recent HBV infections (6.7/105 vs 2.6/105 in the SSP setting and 4.3/105 vs 0.5/105 in one country using PDS). The relatively low numbers of infected donors selected by PDS impeded accurate assessment of the prevalence of recent infections in first-time donations.

Discussion: The data from European countries provide inconclusive evidence that applying PDS reduces the risk of donations being made in the diagnostic window of first-time donors. The impact of PDS on the risk of window-period donations and blood donor management needs further investigation.

Place, publisher, year, edition, pages
2017. Vol. 15, no 6, p. 495-501
Keywords [en]
donors, infectious diseases, screening, selection
National Category
Hematology
Identifiers
URN: urn:nbn:se:uu:diva-340170DOI: 10.2450/2016.0107-16ISI: 000413802600003PubMedID: 27723449OAI: oai:DiVA.org:uu-340170DiVA, id: diva2:1178741
Available from: 2018-01-30 Created: 2018-01-30 Last updated: 2018-01-30Bibliographically approved

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