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Mononuclear metal (II) complexes of a Bis(organoamido) phosphate ligand with antimicrobial activities against Escherichia coli
Indian Sch Mines, Dept Appl Chem, Indian Inst Technol, Dhanbad 826004, Jharkhand, India..
Indian Sch Mines, Dept Environm Sci & Engn, Indian Inst Technol, Dhanbad 826004, Jharkhand, India..
Indian Sch Mines, Dept Environm Sci & Engn, Indian Inst Technol, Dhanbad 826004, Jharkhand, India..
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Molecular Biomimetics.
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2017 (English)In: Applied organometallic chemistry, ISSN 0268-2605, E-ISSN 1099-0739, Vol. 31, no 12, article id e3821Article in journal (Refereed) Published
Abstract [en]

A new tripodal ligand [PO((NHMePy)-Me-2)(3)] (L) ((MePy)-Me-2 = 2-(4-methyl pyridyl)) have been synthesized by treating phosphorous oxychloride with 2-Amino-4-methylpyridine in toluene under refluxing condition. The ligand was appeared as a white solid and characterized by several standard analytical and spectroscopic techniques such as FT-IR, NMR (H-1, C-13{H-1} and P-31{H-1}) and ESI-MS spectroscopy. The ligand (L) undergone metal-assisted hydrolysis of one P-N bond when treated it with hydrated metal nitrates, M(NO3)(2)center dot xH(2)O (M = Zn, Cu, Co and Ni) under hydrothermal reaction condition in DMF-H2O (1:1). This results in the formation of four mononuclear complexes [{PO2((NHMePy)-Me-2)(2)}(2)M] [M = Zn (1), Cu (2), Co (3), Ni (4)], where ligand (L) hydrolyses to a anionic bis(organoamido)phosphate, [PO2((NHMePy)-Me-2)(2)](-). All complexes were completely characterized by various analytical techniques and their solid state molecular structures were established by single crystal X-ray diffraction. All complexes are isostructural with a metal (II) ion situating at the centre of a distorted octahedron. Two tridentate [PO2((NHMePy)-Me-2)(2)](-) ligands are coordinated to metal(II) ion through N- and O-donor atoms, thus neutralizing the charge of the complex. Optical properties of all complexes in solid state have been studied. Moreover, antimicrobial activities of complexes 1-4 have been explored. To the best of our knowledge, this is the first report of such compounds investigated for their antimicrobial activities.

Place, publisher, year, edition, pages
John Wiley & Sons, 2017. Vol. 31, no 12, article id e3821
Keywords [en]
antimicrobial activity, bis(organoamido)phosphate ligand, mononuclear metal complex, P-N bond hydrolysis, X-ray diffraction
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-340479DOI: 10.1002/aoc.3821ISI: 000419195800010OAI: oai:DiVA.org:uu-340479DiVA, id: diva2:1178914
Available from: 2018-01-31 Created: 2018-01-31 Last updated: 2018-01-31Bibliographically approved

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Bhunia, Asamanjoy

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