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An archaeal origin for the actin cytoskeleton: Implications for eukaryogenesis.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology.
2011 (English)In: Communicative & Integrative Biology, ISSN 1942-0889, E-ISSN 1942-0889, Vol. 4, no 6, p. 664-7Article in journal (Refereed) Published
Abstract [en]

A hallmark of the eukaryotic cell is the actin cytoskeleton, involved in a wide array of processes ranging from shape determination and phagocytosis to intracellular transport and cytokinesis. Recently, we reported the discovery of an actin-based cytoskeleton also in Archaea. The archaeal actin ortholog, Crenactin, was shown to belong to a conserved operon, Arcade (actin-related cytoskeleton in Archaea involved in shape determination), encoding an additional set of cytoskeleton-associated proteins. Here, we elaborate on the implications of these findings for the evolutionary relation between archaea and eukaryotes, with particular focus on the possibility that eukaryotic actin and actin-related proteins have evolved from an ancestral archaeal actin gene. Archaeal actin could thus have played an important role in cellular processes essential for the origin and early evolution of the eukaryotic lineage. Further exploration of uncharacterized archaeal lineages is necessary to find additional missing pieces in the evolutionary trajectory that ultimately gave rise to present-day organisms.

Place, publisher, year, edition, pages
2011. Vol. 4, no 6, p. 664-7
National Category
Evolutionary Biology
Identifiers
URN: urn:nbn:se:uu:diva-341056PubMedID: 22446522OAI: oai:DiVA.org:uu-341056DiVA, id: diva2:1180624
Available from: 2018-02-06 Created: 2018-02-06 Last updated: 2018-02-06

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