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The prevalence of Type 2 diabetes is not increased in normal-weight women with PCOS
Oslo Univ Hosp, Div Obstet & Gynecol, Dept Reprod Med, Oslo, Norway..
Oslo Univ Hosp, Div Obstet & Gynecol, Dept Reprod Med, Oslo, Norway..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Reproductive Health.ORCID iD: 0000-0002-2491-2042
Odense Univ Hosp, Dept Gynaecol & Obstet, Odense, Denmark..
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2017 (English)In: Human Reproduction, ISSN 0268-1161, E-ISSN 1460-2350, Vol. 32, no 11, p. 2279-2286Article in journal (Refereed) Published
Abstract [en]

STUDY QUESTION: Is oral glucose tolerance test (OGTT) needed in all women with polycystic ovary syndrome (PCOS)? SUMMARY QNSWER: OGTT is not routinely needed in women with PCOS and BMI < 25 kg/m(2). WHAT IS KNOWN ALREADY: PCOS is associated with insulin resistance and increased prevalence of prediabetes and Type 2 diabetes (T2D) which is closely linked to obesity and possibly age, ethnicity and PCOS phenotype. Several guidelines recommend OGTT upon diagnosis of PCOS and during follow-up. STUDY DESIGN, SIZE, DURATION: A Nordic cross-sectional study including 876 women. PARTICIPANTS/MATERIALS, SETTING, METHODS: The 876 Nordic women with PCOS, aged 14-57 years, were examined for T2D and prediabetes (impaired glucose tolerance [IGT] or impaired fasting glucose (IFG) by OGTT. MAIN RESULT AND THE ROLE OF CHANCE: Of all study subjects 3% (23/876) had T2D, 23% (204/876) prediabetes and 74% (649/876) had normal glucose tolerance (NGT). Increased BMI and waist circumference were significantly (P < 0.001) associated with prevalence of prediabetes and T2D. No normal-weight woman (BMI < 25 kg/m(2)) was diagnosed with (TD)-D-2. The prevalence of BMI >= 25 kg/m(2) was 66% (578/876). 91% of women (21/23) with T2D had BMI >= 30 kg/m(2). Testosterone levels and PCOS phenotype did not predict 2-h glucose levels during OGTT after adjustment for BMI and age. LIMITATIONS, REASONS FOR CAUTION: The present study included cross-sectional data and prospective studies are needed to confirm our results. These results may not apply to populations of other ethnic origin. WIDER IMPLICATIONS OF THE FINDINGS: Routine OGTT may not be indicated in normal-weight women with PCOS.

Place, publisher, year, edition, pages
OXFORD UNIV PRESS , 2017. Vol. 32, no 11, p. 2279-2286
Keywords [en]
Polycystic ovary syndrome, Type 2 diabetes, lean, BMI, oral glucose tolerance test
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
URN: urn:nbn:se:uu:diva-340703DOI: 10.1093/humrep/dex294ISI: 000413450900015PubMedID: 29040530OAI: oai:DiVA.org:uu-340703DiVA, id: diva2:1180814
Funder
Swedish Research Council
Note

The authors consider that the first two authors should be regarded as joint First Authors.

Available from: 2018-02-06 Created: 2018-02-06 Last updated: 2018-02-06Bibliographically approved

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