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A new synthetic granular calcium phosphate compound induces new bone in a sinus lift rabbit model
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Oral and Maxillofacial Surgery.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry.
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2018 (English)In: Journal of Dentistry, ISSN 0300-5712, E-ISSN 1879-176X, Vol. 70, p. 31-39Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: The aim of this study was to investigate if a synthetic granular calcium phosphate compound (CPC) and a composite bisphosphonate-linked hyaluronic acid-calcium phosphate hydrogel (HABP·CaP) induced similar or more amount of bone as bovine mineral in a modified sinus lift rabbit model.

MATERIAL AND METHODS: Eighteen adult male New Zeeland White rabbits, received randomly one of the two test materials on a random side of the face, and bovine mineral as control on the contralateral side. In a sinus lift, the sinus mucosa was elevated and a titanium mini-implant was placed in the alveolar bone. Augmentation material (CPC, HABP·CaP or bovine bone) was applied in the space around the implant. The rabbits were euthanized three months after surgery and qualitative and histomorphometric evaluation were conducted. Histomorphometric evaluation included three different regions of interest (ROIs) and the bone to implant contact on each installed implant.

RESULTS: Qualitative assessment (p = <.05), histomorphometric evaluations (p = < .01), and implant incorporation (p = <.05) showed that CPC and bovine mineral induced similar amount of bone and more than the HABP·CaP hydrogel.

CONCLUSION: CPC induced similar amount of bone as bovine mineral and both materials induced more bone than HABP·CaP hydrogel.

CLINICAL SIGNIFICANCE: The CPC is suggested as a synthetic alternative for augmentations in the maxillofacial area.

Place, publisher, year, edition, pages
2018. Vol. 70, p. 31-39
Keywords [en]
Animal experiments, Bone implant interactions, Bone regeneration, Bone substitutes, Ceramic granules
National Category
Dentistry
Identifiers
URN: urn:nbn:se:uu:diva-341457DOI: 10.1016/j.jdent.2017.12.009ISI: 000425888900004PubMedID: 29258851OAI: oai:DiVA.org:uu-341457DiVA, id: diva2:1181551
Available from: 2018-02-09 Created: 2018-02-09 Last updated: 2018-04-25Bibliographically approved

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Mellgren, TorbjörnHilborn, JönsOssipov, Dmitri A.Thor, Andreas

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Trbakovic, AmelaMellgren, TorbjörnHilborn, JönsOssipov, Dmitri A.Thor, Andreas
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Oral and Maxillofacial SurgeryPolymer Chemistry
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