uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The association between alcohol abuse and neuroendocrine system dysregulation: Race differences in a National sample
Yale Sch Publ Hlth, New Haven, CT USA..
Univ Maryland, Sch Publ Hlth, College Pk, MD 20742 USA..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. Yale Sch Publ Hlth, New Haven, CT USA.;Karolinska Inst, Ctr Mol Med, Solna, Sweden.
Harvard Sch Publ Hlth, Boston, MA USA..
2017 (English)In: Brain, behavior, and immunity, ISSN 0889-1591, E-ISSN 1090-2139, Vol. 66, p. 313-321Article in journal (Refereed) Published
Abstract [en]

Objectives: Health outcomes, including chronic disease and mortality, attributed to or associated with alcohol abuse are discrepant between African Americans and Whites. To date, the topic is not fully understood and few studies conducted have used biomarker indicators of health. We investigated whether the association between alcohol abuse and biomarkers of the neuroendocrine system vary between black or African American and White respondents aged 34-84 from the Midlife in the United States Study (MIDUS) II (2004-2006) (n = 1129). Alcohol abuse was assessed with a modified version of the Michigan Alcohol Screening Test. Ordinary least squared (OLS) regression was used to evaluate whether race moderated the associations between alcohol abuse and four biomarkers-urinary cortisol and serum dehydroepiandrosterone sulfate (DHEA-S), epinephrine and norepinephrine-and two composite summary scores, each consisting of two components that characterize the hypothalamic pituitary adrenal (HPA)-axis and sympathetic nervous systems (SNS), respectively. Covariates included age, sex, education, income, current drinking, smoking, exercise, fast food consumption, heart disease, blood pressure, diabetes, body mass index, medication use, anxiety/depression, sleep duration, and cholesterol markers. Race significantly moderated the associations between alcohol abuse and norepinephrine concentration (chi(2) [1] = 4.48, p = 0.034) and the SNS composite score (chi(2) [1] = 5.83, p = 0.016). Alcohol abuse was associated with higher mean norepinephrine levels (b = 0.26, standard error (SE) = 0.12, p = 0.034) and SNS composite score (b = 0.23, SE = 0.11, p = 0.016) for African Americans compared to Whites. Interestingly, for Whites a paradoxical association between alcohol abuse, norepinephrine and SNS levels was observed; those who abused alcohol had lower mean norepinephrine levels than non-abusers. Race differences in neuroendocrine response could be biological pathways that contribute the excess risk of chronic disease and mortality attributed to alcohol abuse among African Americans compared to Whites. Replication of these analyses in larger cohorts are warranted in addition to further studies of underlying mechanisms among Blacks and Whites separately.

Place, publisher, year, edition, pages
2017. Vol. 66, p. 313-321
Keywords [en]
Alcohol abuse, Neuroendocrine system, Biological markers, Race/ethnicity, Chronic disease, MIDUS
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-341349DOI: 10.1016/j.bbi.2017.07.154ISI: 000414236600030PubMedID: 28751021OAI: oai:DiVA.org:uu-341349DiVA, id: diva2:1182016
Available from: 2018-02-12 Created: 2018-02-12 Last updated: 2018-02-12Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Authority records BETA

Karlsson, Oskar

Search in DiVA

By author/editor
Karlsson, Oskar
By organisation
Department of Pharmaceutical Biosciences
In the same journal
Brain, behavior, and immunity
Neurology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 4 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf