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Depressed serum IgM levels in SLE are restricted to defined subgroups
Karolinska Univ Hosp, Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden..
Karolinska Univ Hosp, Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden..
Karolinska Univ Hosp, Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden..
Karolinska Univ Hosp, Karolinska Inst, Dept Clin Immunol & Transfus Med, Unit Clin Immunol, Stockholm, Sweden..
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2017 (English)In: Clinical Immunology, ISSN 1521-6616, E-ISSN 1521-7035, Vol. 183, p. 304-315Article in journal (Refereed) Published
Abstract [en]

Natural IgM autoantibodies have been proposed to convey protection from autoimmune pathogenesis. Herein, we investigated the IgM responses in 396 systemic lupus erythematosus (SLE) patients, divided into subgroups based on distinct autoantibody profiles. Depressed IgM levels were more common in SLE than in matched population controls. Strikingly, an autoreactivity profile defined by IgG anti-Ro/La was associated with reduced levels of specific natural IgM targeting phosphoiylcholine (PC) antigens and malondialdehyde (MDA) modified-protein, as well as total IgM, while no differences were detected in SLE patients with an autoreactivity profile defined by anti-cardiolipin/beta(2)glycoprotein-I. We also observed an association of reduced IgM levels with the HEA-DRB1*03 allelic variant among SLE patients and controls. Associations of low IgM anti-PC with cardiovascular disease were primarily found in patients without antiphospholipid antibodies. These studies further highlight the clinical relevance of depressed IgM. Our results suggest that low IgM levels in SLE patients reflect immunological and genetic differences between SLE subgroups.

Place, publisher, year, edition, pages
2017. Vol. 183, p. 304-315
Keywords [en]
SLE, Natural IgM, Sjogren's syndrome, Antiphospholipid syndrome, IgM anti-PC, IgM anti-MDA, IgM anti-CWPS, SS, APS, Autoantibodies
National Category
Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:uu:diva-341665DOI: 10.1016/j.clim.2017.09.013ISI: 000414888600042PubMedID: 28919518OAI: oai:DiVA.org:uu-341665DiVA, id: diva2:1182636
Funder
Swedish Research Council, E0395401 201303624Åke Wiberg Foundation, M16-0060Magnus Bergvall Foundation, 2014-00149 2015-00987Swedish Heart Lung Foundation, 20140436Stockholm County Council, 1311-1406The King Gustaf V's Jubilee Foundation, FAI2015-0187 FAI2014-0005Swedish Rheumatism Association, R-639601Available from: 2018-02-14 Created: 2018-02-14 Last updated: 2018-02-27Bibliographically approved

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Rönnelid, Johan

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