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Consequences of Epithelial Inflammasome Activation by Bacterial Pathogens
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab. (Sellin)
ETH Zürich, Institute of Microbiology, Zürich, Switzerland.
ETH Zürich, Institute of Microbiology, Zürich, Switzerland.
2018 (English)In: Journal of Molecular Biology, ISSN 0022-2836, E-ISSN 1089-8638, Vol. 430, no 2, p. 193-206, article id S0022-2836(17)30183-3Article, review/survey (Refereed) Published
Abstract [en]

Inflammasome signaling impinges on the activation of inflammatory caspases (i.e., caspase-1 and caspase-4/5/11) and endows host cells with a sentinel system to sense microbial intrusion and thereby initiate appropriate immune responses. Lately, it has become evident that mammalian inflammasome-dependent responses to infection are not confined solely to cells of hematopoietic origin. Epithelial cells that line the body's mucosal surfaces use inflammasome signaling to sense and counteract pathogenic microorganisms that compromise barrier integrity. Many of the molecular mechanisms of epithelial inflammasome signaling remain unexplored. However, it now seems clear that epithelial inflammasome activation has a profound impact both on the infected cell itself and on its ability to communicate with other cell types of the mucosa. Here, we summarize current knowledge regarding the output of epithelial inflammasome activation during bacterial infection. Well-established downstream effects include epithelial cell death, release of soluble mediators, and subsequent recruitment of effector cell types, including NK cells, mast cells, and neutrophils, to sites of mucosal infection. We discuss the implications of recent findings for antibacterial defense in the mucosa and sketch out areas for future exploration.

Place, publisher, year, edition, pages
2018. Vol. 430, no 2, p. 193-206, article id S0022-2836(17)30183-3
Keywords [en]
NLRC4, NLRP3, epithelium, inflammasomes, interleukin-18
National Category
Microbiology in the medical area
Identifiers
URN: urn:nbn:se:uu:diva-342056DOI: 10.1016/j.jmb.2017.03.031ISI: 000423655900006PubMedID: 28454742OAI: oai:DiVA.org:uu-342056DiVA, id: diva2:1183628
Funder
Swedish Research Council, 2015-00635Available from: 2018-02-19 Created: 2018-02-19 Last updated: 2018-05-08Bibliographically approved

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