uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Vascular heterogeneity and specialization in development and disease
Max Planck Inst Heart & Lung Res, Angiogenesis & Metab Lab, Ludwigstr 43, D-61231 Bad Nauheim, Germany.;Int Inst Mol & Cell Biol, PL-02109 Warsaw, Poland.;DZHK German Ctr Cardiovasc Res, Partner Site Frankfurt, D-13347 Berlin, Germany..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology.ORCID iD: 0000-0002-9338-1257
2017 (English)In: Nature reviews. Molecular cell biology, ISSN 1471-0072, E-ISSN 1471-0080, Vol. 18, no 8, p. 477-494Article, review/survey (Refereed) Published
Abstract [en]

Blood and lymphatic vessels pervade almost all body tissues and have numerous essential roles in physiology and disease. The inner lining of these networks is formed by a single layer of endothelial cells, which is specialized according to the needs of the tissue that it supplies. Whereas the general mechanisms of blood and lymphatic vessel development are being defined with increasing molecular precision, studies of the processes of endothelial specialization remain mostly descriptive. Recent insights from genetic animal models illuminate how endothelial cells interact with each other and with their tissue environment, providing paradigms for vessel type- and organ-specific endothelial differentiation. Delineating these governing principles will be crucial for understanding how tissues develop and maintain, and how their function becomes abnormal in disease.

Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP , 2017. Vol. 18, no 8, p. 477-494
National Category
Cell Biology
Identifiers
URN: urn:nbn:se:uu:diva-341859DOI: 10.1038/nrm.2017.36ISI: 000406040900008OAI: oai:DiVA.org:uu-341859DiVA, id: diva2:1183641
Funder
Swedish Research CouncilSwedish Cancer SocietyEU, European Research CouncilKnut and Alice Wallenberg FoundationAvailable from: 2018-02-19 Created: 2018-02-19 Last updated: 2018-02-19Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full text

Authority records BETA

Mäkinen, Taija

Search in DiVA

By author/editor
Mäkinen, Taija
By organisation
Vascular Biology
In the same journal
Nature reviews. Molecular cell biology
Cell Biology

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 23 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf