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Dissecting evolution and disease using comparative vertebrate genomics
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab. Broad Inst Massachusetts Inst Technol & Harvard, 415 Main St, Cambridge, MA 02142 USA.ORCID iD: 0000-0001-8338-0253
2017 (English)In: Nature reviews genetics, ISSN 1471-0056, E-ISSN 1471-0064, Vol. 18, no 10, p. 624-636Article, review/survey (Refereed) Published
Abstract [en]

With the generation of more than 100 sequenced vertebrate genomes in less than 25 years, the key question arises of how these resources can be used to inform new or ongoing projects. In the past, this diverse collection of sequences from human as well as model and non-model organisms has been used to annotate the human genome and to increase the understanding of human disease. In the future, comparativevertebrate genomics in conjunction with additional genomic resources will yield insights into the processes of genome function, evolution, speciation, selection and adaptation, as well as the quantification of species diversity. In this Review, we discuss how the genomics of non-human organisms can provide insights into vertebrate biology and how this can contribute to the understanding of human physiology and health.

Place, publisher, year, edition, pages
2017. Vol. 18, no 10, p. 624-636
National Category
Genetics
Identifiers
URN: urn:nbn:se:uu:diva-342161DOI: 10.1038/nrg.2017.51ISI: 000410808600004PubMedID: 28736437OAI: oai:DiVA.org:uu-342161DiVA, id: diva2:1183791
Funder
Swedish Research Council Formas, 221-2012-1531Swedish Research CouncilEU, European Research CouncilKnut and Alice Wallenberg FoundationAvailable from: 2018-02-19 Created: 2018-02-19 Last updated: 2018-03-19Bibliographically approved

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Meadows, JenniferLindblad-Toh, Kerstin

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