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To pace or not to pace: a pilot study of four- and five-gaited Icelandic horses homozygous for the DMRT3 'Gait Keeper' mutation
Swedish Univ Agr Sci, Dept Anim Breeding & Genet, S-75007 Uppsala, Sweden..
Swedish Univ Agr Sci, Dept Anim Breeding & Genet, S-75007 Uppsala, Sweden..
IHBC AB, S-74494 Knubbo, Morgongava, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Swedish Univ Agr Sci, Dept Anim Breeding & Genet, S-75007 Uppsala, Sweden.; Texas A&M Univ, Dept Vet Integrat Biosci, College Stn, TX 77843 USA..
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2017 (English)In: Animal Genetics, ISSN 0268-9146, E-ISSN 1365-2052, Vol. 48, no 6, p. 694-697Article in journal (Refereed) Published
Abstract [en]

The Icelandic horse is a breed known mainly for its ability to perform the ambling four-beat gait 'tolt' and the lateral two-beat gait pace. The natural ability of the breed to perform these alternative gaits is highly desired by breeders. Therefore, the discovery that a nonsense mutation (C>A) in the DMRT3 gene was the main genetic factor for horses' ability to perform gaits in addition to walk, trot and canter was of great interest. Although several studies have demonstrated that homozygosity for the DMRT3 mutation is important for the ability to pace, only about 70% of the homozygous mutant (AA) Icelandic horses are reported to pace. The aim of the study was to genetically compare four-and five-gaited (i.e. horses with and without the ability to pace) AA Icelandic horses by performing a genome-wide association (GWA) analysis. All horses (n = 55) were genotyped on the 670K Axiom Equine Genotyping Array, and a GWA analysis was performed using the GENABEL package in R. No SNP demonstrated genome-wide significance, implying that the ability to pace goes beyond the presence of a single gene variant. Despite its limitations, the current study provides additional information regarding the genetic complexity of pacing ability in horses. However, to fully understand the genetic differences between four-and five-gaited AA horses, additional studies with larger sample materials and consistent phenotyping are needed.

Place, publisher, year, edition, pages
2017. Vol. 48, no 6, p. 694-697
Keywords [en]
Equine, gaits, GWAS, locomotion pattern
National Category
Genetics
Identifiers
URN: urn:nbn:se:uu:diva-342200DOI: 10.1111/age.12610ISI: 000415368600010PubMedID: 29023800OAI: oai:DiVA.org:uu-342200DiVA, id: diva2:1184020
Funder
Swedish Research Council, 621-2012-4666Swedish Research Council Formas, 221-2013-1661Available from: 2018-02-20 Created: 2018-02-20 Last updated: 2018-02-20Bibliographically approved

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