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Overall and peripheral lung function assessment by spirometry and forced oscillation technique in relation to asthma diagnosis and control.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Paediatric Inflammation Research.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Paediatric Inflammation Research.
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2017 (English)In: Clinical and Experimental Allergy, ISSN 0954-7894, E-ISSN 1365-2222, Vol. 47, no 12, p. 1546-1554Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Classic spirometry is effort dependent and of limited value in assessing small airways. Peripheral airway involvement, and relation to poor control, in asthma, has been highlighted recently. Forced oscillation technique (FOT) offers an effort-independent assessment of overall and peripheral lung mechanics. We studied the association between lung function variables, obtained either by spirometry or multifrequency (5, 11 and 19 Hz) FOT, and asthma diagnosis and control.

METHODS: ), resistance difference between 5-19 Hz (R5-R19) and Asthma Control Test scores were determined in 234 asthmatic and 60 healthy subjects (aged 13-39 years). We used standardized lung function variables in logistic regression analyses, unadjusted and adjusted for age, height, gender and weight.

RESULTS: and R5-R19) were associated with uncontrolled asthma (P-values < .05).

CONCLUSIONS: /FVC, supporting a complementary role for FOT. Asthma control was related to FOT measures of peripheral airways, suggesting a potential use in identifying such involvement. Further studies are needed to determine a clinical value and relevant reference values in children, for the multifrequency FOT measurements.

Place, publisher, year, edition, pages
2017. Vol. 47, no 12, p. 1546-1554
Keyword [en]
asthma, asthma control, forced oscillation technique, lung function, small airways, spirometry
National Category
Respiratory Medicine and Allergy
Identifiers
URN: urn:nbn:se:uu:diva-342404DOI: 10.1111/cea.13035ISI: 000416430300005PubMedID: 28940832OAI: oai:DiVA.org:uu-342404DiVA, id: diva2:1184155
Available from: 2018-02-20 Created: 2018-02-20 Last updated: 2018-03-01Bibliographically approved

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Heijkenskjöld Rentzhog, CharlotteJanson, ChristerBorres, Magnus PNordvall, LennartAlving, KjellMalinovschi, Andrei

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Heijkenskjöld Rentzhog, CharlotteJanson, ChristerBorres, Magnus PNordvall, LennartAlving, KjellMalinovschi, Andrei
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Paediatric Inflammation ResearchLung- allergy- and sleep researchUCR-Uppsala Clinical Research CenterClinical Physiology
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