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Systemic AA amyloidosis in the red fox (Vulpes vulpes)
Swedish Univ Agr Sci, Dept Anat Physiol & Biochem, S-75007 Uppsala, Sweden.;Karolinska Inst, Div Neurogeriatr, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc NVS, S-14157 Huddinge, Sweden..
Karolinska Inst, Dept Med Biochem & Biophys MBB, S-17177 Stockholm, Sweden..
Karolinska Inst, Ctr Prote Karolinska PKKI, S-17177 Stockholm, Sweden..
Natl Vet Inst SVA, Dept Pathol & Wildlife Dis, S-75189 Uppsala, Sweden..
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2017 (English)In: Protein Science, ISSN 0961-8368, E-ISSN 1469-896X, Vol. 26, no 11, p. 2312-2318Article in journal (Refereed) Published
Abstract [en]

Amyloid A (AA) amyloidosis occurs spontaneously in many mammals and birds, but the prevalence varies considerably among different species, and even among subgroups of the same species. The Blue fox and the Gray fox seem to be resistant to the development of AA amyloidosis, while Island foxes have a high prevalence of the disease. Herein, we report on the identification of AA amyloidosis in the Red fox (Vulpes vulpes). Edman degradation and tandem MS analysis of proteolyzed amyloid protein revealed that the amyloid partly was composed of full-length SAA. Its amino acid sequence was determined and found to consist of 111 amino acid residues. Based on inter-species sequence comparisons we found four residue exchanges (Ser31, Lys63, Leu71, Lys72) between the Red and Blue fox SAAs. Lys63 seems unique to the Red fox SAA. We found no obvious explanation to how these exchanges might correlate with the reported differences in SAA amyloidogenicity. Furthermore, in contrast to fibrils from many other mammalian species, the isolated amyloid fibrils from Red fox did not seed AA amyloidosis in a mouse model.

Place, publisher, year, edition, pages
WILEY , 2017. Vol. 26, no 11, p. 2312-2318
Keywords [en]
amyloid, protein aggregation, disease, seeding, serum amyloid A
National Category
Medical Bioscience
Identifiers
URN: urn:nbn:se:uu:diva-340697DOI: 10.1002/pro.3264ISI: 000413668900019PubMedID: 28791746OAI: oai:DiVA.org:uu-340697DiVA, id: diva2:1184245
Funder
Swedish Research CouncilAvailable from: 2018-02-20 Created: 2018-02-20 Last updated: 2018-02-20Bibliographically approved

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Rising, AnnaIhse, ElisabetWestermark, GunillaWestermark, Per

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Clinical and experimental pathologyDepartment of Medical Cell Biology
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