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Elevated inflammation in association with alcohol abuse among Blacks but not Whites: results from the MIDUS biomarker study
Department of Social and Behavioral Sciences, Yale School of Public Health, New Haven, USA.
Department of Epidemiology and Biostatistics, University of Maryland School of Public Health, USA.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. Center for Molecular Medicine, Karolinska Institute, Solna, Sweden.
Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, USA.
2017 (English)In: Journal of behavioral medicine, ISSN 0160-7715, E-ISSN 1573-3521Article in journal (Refereed) Epub ahead of print
Abstract [en]

Some studies document racial disparities in self-reported health associated with alcohol use and abuse. However, few studies examined biomarkers that underlie the onset of alcohol-related chronic diseases. We investigated whether the association between alcohol abuse and five biomarkers of inflammation (CRP, IL-6, fibrinogen, E-selectin, sICAM-1) vary between Black and White Americans aged 35 to 84 (n = 1173) from the Midlife in the United States Biomarker Study. Multivariable Ordinary Least Squares regressions were used to assess Black-White differences in the association between alcohol abuse and the biomarkers. Race moderated the association between alcohol abuse and CRP (b = 0.56, SE = 0.28, p = 0.048), IL-6 (b = 0.65, SE = 0.22, p = 0.004), and a composite inflammation score (b = 0.014, SE = 0.07, p = 0.041). These findings potentially shed light for why alcohol has a stronger negative association with poorer health for Blacks compared to Whites. Analysis should be replicated in larger prospective cohorts.

Place, publisher, year, edition, pages
2017.
Keywords [en]
Alcohol abuse, Biological markers, Chronic disease, Inflammation, MIDUS, Race/ethnicity
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:uu:diva-342427DOI: 10.1007/s10865-017-9905-4PubMedID: 29230616OAI: oai:DiVA.org:uu-342427DiVA, id: diva2:1184254
Available from: 2018-02-20 Created: 2018-02-20 Last updated: 2018-03-22Bibliographically approved

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Karlsson, Oskar

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