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The environmental neurotoxin β-N-methylamino-l-alanine (l-BMAA) is deposited into birds' eggs
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental toxicology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental toxicology.ORCID iD: 0000-0002-5386-2400
2018 (English)In: Ecotoxicology and Environmental Safety, ISSN 0147-6513, E-ISSN 1090-2414, Vol. 147, p. 720-724Article in journal (Refereed) Published
Abstract [en]

C-carboxyl-labeled BMAA were compared. The results revealed a pronounced incorporation of radioactivity in the eggs, predominantly in the yolk but also in the albumen. Imaging analysis showed that the concentrations of radioactivity in the liver decreased about seven times between the 24h and the 72h time points, while the concentrations in egg yolk remained largely unchanged. At 72h the egg yolk contained about five times the concentration of radioactivity in the liver. Both BMAA preparations gave rise to similar distribution pattern in the bird tissues and in the eggs, indicating metabolic stability of the labeled groups. The demonstrated deposition into eggs warrants studies of BMAAs effects on bird development. Moreover, birds' eggs may be a source of human BMAA exposure, provided that the laying birds are exposed to BMAA via their diet.

Place, publisher, year, edition, pages
2018. Vol. 147, p. 720-724
Keywords [en]
Birds' eggs, Cyanobacterial neurotoxin, Developmental toxicity, Human exposure, Secretion
National Category
Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:uu:diva-342429DOI: 10.1016/j.ecoenv.2017.09.032ISI: 000416199700090PubMedID: 28942274OAI: oai:DiVA.org:uu-342429DiVA, id: diva2:1184258
Funder
Swedish Research Council FormasAvailable from: 2018-02-20 Created: 2018-02-20 Last updated: 2018-03-02Bibliographically approved

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Andersson, MarieKarlsson, OskarBrandt, Ingvar

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