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Percutaneous coronary intervention and antiplatelet therapy in patients with atrial fibrillation receiving apixaban or warfarin: Insights from the ARISTOTLE trial
Duke University School of Medicine, Durham, USA.
Duke University School of Medicine, Durham, USA.
Inova Heart and Vascular Institute, Fairfax, USA.
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2018 (English)In: American Heart Journal, ISSN 0002-8703, E-ISSN 1097-6744, Vol. 197, p. 133-141, article id S0002-8703(17)30360-5Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: We assessed antiplatelet therapy use and outcomes in patients undergoing percutaneous coronary intervention (PCI) during the ARISTOTLE trial.

METHODS: Patients were categorized based on the occurrence of PCI during follow-up (median 1.8 years); PCI details and outcomes post-PCI are reported. Of the 18,201 trial participants, 316 (1.7%) underwent PCI (152 in apixaban group, 164 in warfarin group).

RESULTS: inhibitor; 32% received antiplatelet agents without OAC. Post-PCI, patients assigned to apixaban versus warfarin had numerically similar rates of major bleeding (5.93 vs 6.73 events/100 patient-years; P = .95) and stroke (2.74 vs 1.84 events/100 patient-years; P = .62).

CONCLUSIONS: PCI occurred infrequently during follow-up. Most patients on study drug at the time of PCI remained on study drug in the peri-PCI period; 19% continued the study drug without interruption. Antiplatelet therapy use post-PCI was variable, although most patients received DAPT. Additional data are needed to guide the use of antithrombotics in patients undergoing PCI.

Place, publisher, year, edition, pages
New York, 2018. Vol. 197, p. 133-141, article id S0002-8703(17)30360-5
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:uu:diva-342515DOI: 10.1016/j.ahj.2017.11.005ISI: 000425723700016PubMedID: 29447773OAI: oai:DiVA.org:uu-342515DiVA, id: diva2:1184537
Available from: 2018-02-21 Created: 2018-02-21 Last updated: 2018-05-03Bibliographically approved

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Wallentin, Lars

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