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High pressure inertial focusing for separating and concentrating bacteria at high throughput
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences. Univ Autonoma Barcelona, Dept Genet & Microbiol, Barcelona, Spain..
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.ORCID iD: 0000-0002-3966-0220
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2017 (English)In: Journal of Micromechanics and Microengineering, ISSN 0960-1317, E-ISSN 1361-6439, Vol. 27, no 8, article id 084001Article in journal (Refereed) Published
Abstract [en]

Inertial focusing is a promising microfluidic technology for concentration and separation of particles by size. However, there is a strong correlation of increased pressure with decreased particle size. Theory and experimental results for larger particles were used to scale down the phenomenon and find the conditions that focus 1 mu m particles. High pressure experiments in robust glass chips were used to demonstrate the alignment. We show how the technique works for 1 mu m spherical polystyrene particles and for Escherichia coli, not being harmful for the bacteria at 50 mu l min(-1). The potential to focus bacteria, simplicity of use and high throughput make this technology interesting for healthcare applications, where concentration and purification of a sample may be required as an initial step.

Place, publisher, year, edition, pages
IOP PUBLISHING LTD , 2017. Vol. 27, no 8, article id 084001
Keywords [en]
bacteria separation, particle separation, inertial focusing, high pressure, glass chips, PDMS, microfluidic channel
National Category
Condensed Matter Physics Other Materials Engineering Analytical Chemistry Physical Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-329919DOI: 10.1088/1361-6439/aa6b14ISI: 000404540500001OAI: oai:DiVA.org:uu-329919DiVA, id: diva2:1184782
Funder
EU, Horizon 2020, 644669Available from: 2018-02-22 Created: 2018-02-22 Last updated: 2018-04-23Bibliographically approved

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Cruz, JavierGraells, TiscarAndersson, MartinMalmström, JonasWu, Zhigang G.Hjort, Klas

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Cruz, JavierGraells, TiscarAndersson, MartinMalmström, JonasWu, Zhigang G.Hjort, Klas
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Microsystems TechnologyDepartment of Engineering SciencesDepartment of Medical Biochemistry and Microbiology
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Journal of Micromechanics and Microengineering
Condensed Matter PhysicsOther Materials EngineeringAnalytical ChemistryPhysical Chemistry

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