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CKM Glu83Gly Is Associated With Blunted Creatine Kinase Variation, but Not With Myalgia
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2017 (English)In: Circulation: Cardiovascular Genetics, ISSN 1942-325X, E-ISSN 1942-3268, Vol. 10, no 4, article id e001737Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Glu83Gly (rs11559024) with constitutive creatine phosphokinase (CK) levels, CK variation, and inducibility. Given the diagnostic importance of CK in determining muscle damage, we tested the association of the variant with myalgia.

METHODS AND RESULTS: ) lower for carriers of the variant, respectively. The variant was not associated with myalgia (odds ratio, 0.84; 95% confidence interval, 0.52-1.38).

CONCLUSIONS: This study highlights that a genetic factor known to be associated with constitutive CK levels is also associated with CK variability and inducibility. This is discussed in the context of evidence to suggest that the variant has an impact on inducibility of CK by trauma through a previously reported case of a homozygous carrier. However, the lack of association between the variant and myalgia suggests that it cannot reliably be used as a biomarker for muscle symptoms.

Place, publisher, year, edition, pages
2017. Vol. 10, no 4, article id e001737
Keywords [en]
creatine kinase, diabetes mellitus, genetics, muscles, myalgia, statins
National Category
Clinical Laboratory Medicine
Identifiers
URN: urn:nbn:se:uu:diva-342622DOI: 10.1161/CIRCGENETICS.117.001737ISI: 000407206100012PubMedID: 28790154OAI: oai:DiVA.org:uu-342622DiVA, id: diva2:1184922
Available from: 2018-02-22 Created: 2018-02-22 Last updated: 2018-09-24Bibliographically approved

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