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Assessment of 105 Patients with Angiotensin Converting Enzyme-Inhibitor Induced Angioedema
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical pharmacogenomics and osteoporosis. Uppsala University, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0002-6368-2622
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2017 (English)In: International Journal of Otolaryngology, ISSN 1687-9201, E-ISSN 1687-921X, Vol. 2017, article id 1476402Article in journal (Refereed) Published
Abstract [en]

Objective. To asses a cohort of 105 consecutive patients with angiotensin converting enzyme-inhibitor induced angioedema withregard to demographics, risk factors, family history of angioedema, hospitalization, airway management, outcome, and use ofdiagnostic codes used for the condition.

Study Design. Cohort study.

Methods.This was a retrospective cohort study of 105 patientswith angiotensin converting enzyme-inhibitor induced angioedema in the period 1995–2014.

Results. The cohort consisted of 67females and 38 males (F :Mratio 1.8), with a mean age of 63 [range 26–86] years. Female gender was associated with a significantlyhigher risk of angiotensin converting enzyme-inhibitor induced angioedema. 6.7% had a positive family history of angioedema.Diabetes seemed to be a protective factor with regard to angioedema. 95% experienced angioedema of the head and neck. 4.7%needed intubation or tracheostomy. 74 admissions took place during the study period with a total of 143 days spent in the hospital.The diagnosis codes most often used for this condition were “DT783 Quincke’s oedema” and “DT78.4 Allergy unspecified”.Complement C1 inhibitor was normal in all tested patients.

Conclusion. Female gender predisposes to angiotensin convertingenzyme-inhibitor induced angioedema, whereas diabetes seems to be a protective factor.

Place, publisher, year, edition, pages
2017. Vol. 2017, article id 1476402
National Category
Otorhinolaryngology
Research subject
Pharmacology
Identifiers
URN: urn:nbn:se:uu:diva-342586DOI: 10.1155/2017/1476402PubMedID: 28286522OAI: oai:DiVA.org:uu-342586DiVA, id: diva2:1184925
Available from: 2018-02-22 Created: 2018-02-22 Last updated: 2018-03-15Bibliographically approved

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