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Genes encoding cuticular proteins are components of the Nimrod gene cluster in Drosophila
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2017 (English)In: Insect Biochemistry and Molecular Biology, ISSN 0965-1748, E-ISSN 1879-0240, Vol. 87, p. 45-54Article in journal (Refereed) Published
Abstract [en]

The Nimrod gene cluster, located on the second chromosome of Drosophila melanogaster, is the largest synthenic unit of the Drosophila genome. Nimrod genes show blood cell specific expression and code for phagocytosis receptors that play a major role in fruit fly innate immune functions. We previously identified three homologous genes (vajk-1, vajk-2 and vajk-3) located within the Nimrod cluster, which are unrelated to the Nimrod genes, but are homologous to a fourth gene (vajk-4) located outside the cluster. Here we show that, unlike the Nimrod candidates, the Vajk proteins are expressed in cuticular structures of the late embryo and the late pupa, indicating that they contribute to cuticular barrier functions.

Place, publisher, year, edition, pages
2017. Vol. 87, p. 45-54
Keywords [en]
Cuticle development, Drosophila, Gene cluster, Innate immunity, Nimrod, Trachea
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-342841DOI: 10.1016/j.ibmb.2017.06.006ISI: 000408289200005PubMedID: 28633893OAI: oai:DiVA.org:uu-342841DiVA, id: diva2:1185253
Funder
Carl Tryggers foundation Knut and Alice Wallenberg FoundationSwedish Cancer SocietyStiftelsen Olle Engkvist ByggmästareAvailable from: 2018-02-23 Created: 2018-02-23 Last updated: 2018-03-22Bibliographically approved

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Williams, Michael J.

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