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Association between long sleep duration and increased risk of obesity and type 2 diabetes: A review of possible mechanisms
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.ORCID iD: 0000-0003-3992-5812
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.ORCID iD: 0000-0002-9052-8372
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.ORCID iD: 000-0002-8911-4068
2018 (English)In: Sleep Medicine Reviews, ISSN 1087-0792, E-ISSN 1532-2955, Vol. 40, p. 127-134Article, review/survey (Refereed) Published
Abstract [en]

For the last two decades research has revealed an alarming association between short sleep duration and metabolic disorders. In tandem, the hormonal, behavioral, and genetic mechanisms underlying this relationship have been extensively investigated and reviewed. However, emerging evidence is revealing that excessive sleep duration has remarkably similar deleterious effects. Unfortunately, to date there has been little attention to what drives this connection. This narrative review therefore aims to summarize existing epidemiological findings, experimental work, and most importantly putative molecular and behavioral mechanisms connecting excessive sleep duration with both obesity and type 2 diabetes mellitus. It will also address recent findings suggesting a worrisome bidirectional effect such that metabolic disorders create a positive feedback loop which further perpetuates excessive sleep.

Place, publisher, year, edition, pages
2018. Vol. 40, p. 127-134
Keywords [en]
Chronotype, Long sleep duration, Obesity, Positive feedback loop, Putative mechanisms, Type 2 diabetes mellitus
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:uu:diva-342958DOI: 10.1016/j.smrv.2017.11.001ISI: 000438201300012PubMedID: 29233612OAI: oai:DiVA.org:uu-342958DiVA, id: diva2:1185379
Funder
Novo Nordisk, NNF14OC0009349The Swedish Brain Foundation, FO2016-0092Swedish Research Council, 2015-03100Available from: 2018-02-23 Created: 2018-02-23 Last updated: 2018-11-12Bibliographically approved

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Tan, XiaoChapman, Colin DCedernaes, JonathanBenedict, Christian

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