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Fundamentals of ion mobility spectrometry
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Biochemistry.ORCID iD: 0000-0002-9804-5009
2018 (English)In: Current opinion in chemical biology, ISSN 1367-5931, E-ISSN 1879-0402, Vol. 42, p. 51-59, article id S1367-5931(17)30122-9Article, review/survey (Refereed) Published
Abstract [en]

Fundamental questions in ion mobility spectrometry have practical implications for analytical applications in general, and omics in particular, in three respects. (1) Understanding how ion mobility and collision cross section values depend on the collision gas, on the electric field and on temperature is crucial to ascertain their transferability across instrumental platforms. (2) Predicting collision cross section values for new analytes is necessary to exploit the full potential of ion mobility in discovery workflows. (3) Finally, understanding the fate of ion structures in the gas phase is essential to infer meaningful information on solution structures based on gas-phase ion mobility measurements. We review here the most recent advances in ion mobility fundamentals, relevant to these three aspects.

Place, publisher, year, edition, pages
2018. Vol. 42, p. 51-59, article id S1367-5931(17)30122-9
National Category
Analytical Chemistry Structural Biology
Research subject
Chemistry with specialization in Biophysics
Identifiers
URN: urn:nbn:se:uu:diva-342974DOI: 10.1016/j.cbpa.2017.10.022ISI: 000427343000008PubMedID: 29154177OAI: oai:DiVA.org:uu-342974DiVA, id: diva2:1185398
Funder
Swedish Research CouncilEU, FP7, Seventh Framework Programme, 2015-00559EU, FP7, Seventh Framework Programme, 616551
Available from: 2018-02-23 Created: 2018-02-23 Last updated: 2018-04-05Bibliographically approved

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Marklund, Erik

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