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Short-term side effects and attitudes towards second donation: A comparison of related and unrelated haematopoietic stem cell donors.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Haematology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Haematology. Karolinska University Hospital, Stockholm, Sweden . (Hematologi)
Karolinska University Hospital, Stockholm, Sweden .
Copenhagen University Hospital, Copenhagen, Denmark.
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2017 (English)In: Journal of clinical apheresis, ISSN 0733-2459, E-ISSN 1098-1101Article in journal (Refereed) Epub ahead of print
Abstract [en]

The Nordic Register of Haematopoietic Stem Cell Donors (NRHSD) has registered related and unrelated donors from 10 transplant centres in Sweden, Norway, Finland and Denmark since 1998. We present a prospective, observational study of 1,957 donors, focusing mainly on the differences between related and unrelated donors. Related donors are reported to have more comorbidities, but similar side effects compared with unrelated donors. Side effects after BM or PBSC donation are generally of short duration and in this study no deaths, myocardial infarctions, splenic ruptures, or thromboembolic events are reported. Interestingly, related donors express more hesitancy towards donating again when asked 1 month after donation.

Place, publisher, year, edition, pages
2017.
Keywords [en]
bone marrow donation, granulocyte colony stimulating factor, healthy donors, peripheral blood stem cell donation
National Category
Hematology
Identifiers
URN: urn:nbn:se:uu:diva-342995DOI: 10.1002/jca.21576PubMedID: 28833474OAI: oai:DiVA.org:uu-342995DiVA, id: diva2:1185428
Available from: 2018-02-24 Created: 2018-02-24 Last updated: 2018-03-28Bibliographically approved

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Pahnke, SimonLarfors, GunnarHägglund, Hans

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