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Changing the threshold-Signals and mechanisms of mast cell priming
Czech Acad Sci, Inst Mol Genet, Dept Signal Transduct, Prague, Czech Republic.
Karolinska Univ Hosp, Karolinska Inst & Clin Immunol & Transfus Med, Dept Med, Immunol & Allergy Unit, Stockholm, Sweden.
Czech Acad Sci, Inst Mol Genet, Dept Signal Transduct, Prague, Czech Republic.
Karolinska Univ Hosp, Karolinska Inst & Clin Immunol & Transfus Med, Dept Med, Immunol & Allergy Unit, Stockholm, Sweden; Univ Alberta, Alberta Resp Ctr, Edmonton, AB, Canada; Univ Alberta, Dept Med, Edmonton, AB, Canada.
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2018 (English)In: Immunological Reviews, ISSN 0105-2896, E-ISSN 1600-065X, Vol. 282, no 1, p. 73-86Article in journal (Refereed) Published
Abstract [en]

Mast cells play a key role in allergy and other inflammatory diseases involving engagement of multivalent antigen with IgE bound to high-affinity IgE receptors (FcεRIs). Aggregation of FcεRIs on mast cells initiates a cascade of signaling events that eventually lead to degranulation, secretion of leukotrienes and prostaglandins, and cytokine and chemokine production contributing to the inflammatory response. Exposure to pro-inflammatory cytokines, chemokines, bacterial and viral products, as well as some other biological products and drugs, induces mast cell transition from the basal state into a primed one, which leads to enhanced response to IgE-antigen complexes. Mast cell priming changes the threshold for antigen-mediated activation by various mechanisms, depending on the priming agent used, which alone usually do not induce mast cell degranulation. In this review, we describe the priming processes induced in mast cells by various cytokines (stem cell factor, interleukins-4, -6 and -33), chemokines, other agents acting through G protein-coupled receptors (adenosine, prostaglandin E2, sphingosine-1-phosphate, and β-2-adrenergic receptor agonists), toll-like receptors, and various drugs affecting the cytoskeleton. We will review the current knowledge about the molecular mechanisms behind priming of mast cells leading to degranulation and cytokine production and discuss the biological effects of mast cell priming induced by several cytokines.

Place, publisher, year, edition, pages
John Wiley & Sons, 2018. Vol. 282, no 1, p. 73-86
Keywords [en]
cell priming, chemokines, cytokine receptors, cytokines, high-affinity IgE receptor, mast cell
National Category
Immunology in the medical area
Identifiers
URN: urn:nbn:se:uu:diva-343008DOI: 10.1111/imr.12625ISI: 000424876400006PubMedID: 29431203OAI: oai:DiVA.org:uu-343008DiVA, id: diva2:1185445
Funder
Swedish Research Council, K2012-57X-13029-14-6Available from: 2018-02-24 Created: 2018-02-24 Last updated: 2018-05-15Bibliographically approved

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Nilsson, Gunnar P.

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