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Symptom burden profile in myelofibrosis patients with thrombocytopenia: Lessons and unmet needs
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2017 (English)In: Leukemia research: a Forum for Studies on Leukemia and Normal Hemopoiesis, ISSN 0145-2126, E-ISSN 1873-5835, Vol. 63, p. 34-40Article in journal (Refereed) Published
Abstract [en]

Myelofibrosis is a myeloproliferative neoplasm associated with progressive cytopenias and high symptom burden. MF patients with thrombocytopenia have poor prognosis but the presence of thrombocytopenia frequently precludes the use of JAK2 inhibitors. In this study, we assessed quality of life and symptom burden in 418 MF patients with (n = 89) and without (n = 329) thrombocytopenia using prospective data from the MPN-QOL study group database, including the Myeloproliferative Neoplasm Symptom Assessment Form (MPN-SAF) and Total Symptom Score (MPN10). Thrombocytopenia, defined as platelet count < 100 x10(9)/L (moderate 51-100 x 10(9)/L; severe <= 50 x10(9)/L), was associated with anemia (76% vs. 45%, p < 0.001), leukopenia (29% vs. 11%, p < 0.001), and need for red blood cell transfusion (35% vs. 19%, p = 0.002). Thrombocytopenic patients had more fatigue, early satiety, inactivity, dizziness, sad mood, cough, night sweats, itching, fever, and weight loss; total symptom scores were also higher (33 vs. 24, p < 0.001). Patients with severe thrombocytopenia were more likely to have anemia (86% vs. 67%, p = 0.04), leukopenia (40% vs. 20%, p = 0.04), and transfusion requirements (51% vs. 20%, p = 0.002) but few differences in symptoms when compared to patients with moderate thrombocytopenia. These results suggest that MF patients with thrombocytopenia experience greater symptomatic burden than MF patients without thrombocytopenia and may benefit from additional therapies.

Place, publisher, year, edition, pages
2017. Vol. 63, p. 34-40
Keyword [en]
Myelofibrosis, Myeloproliferative neoplasm, Quality of life, Symptomatology, Thrombocytopenia
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-343027DOI: 10.1016/j.leukres.2017.10.002ISI: 000416744700006PubMedID: 29096334OAI: oai:DiVA.org:uu-343027DiVA, id: diva2:1185449
Available from: 2018-02-25 Created: 2018-02-25 Last updated: 2018-03-01Bibliographically approved

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Birgegård, Gunnar

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