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Verification of a Method for Measuring Parkinson's Disease Related Temporal Irregularity in Spiral Drawings
Dalarna Univ, Falun, Sweden.
Örebro Univ, Örebro, Sweden.
Dalarna Univ, Falun, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurology.ORCID iD: 0000-0001-9776-7715
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2017 (English)In: Sensors, ISSN 1424-8220, E-ISSN 1424-8220, Vol. 17, no 10, article id 2431Article in journal (Refereed) Published
Abstract [en]

-value = 0.02). Test-retest reliability of TIS was good with Intra-class Correlation Coefficient of 0.81. When assessing changes in relation to treatment, TIS contained some information to capture changes from Off to On and wearing off effects. However, the correlations between TIS and clinical scores (UPDRS and Dyskinesia) were weak. TIS was able to differentiate spiral drawings drawn by patients in an advanced stage from those drawn by healthy subjects, and TIS had good test-retest reliability. TIS was somewhat responsive to single-dose levodopa treatment. Since TIS is an upper limb high-frequency-based measure, it cannot be detected during clinical assessment.

Place, publisher, year, edition, pages
2017. Vol. 17, no 10, article id 2431
Keywords [en]
Parkinson’s disease, approximate entropy, complexity, motor assessment, smartphone, spiral tests, temporal irregularity, timing variability
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-343106DOI: 10.3390/s17102341ISI: 000414931500183PubMedID: 29027941OAI: oai:DiVA.org:uu-343106DiVA, id: diva2:1185502
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VINNOVAAvailable from: 2018-02-25 Created: 2018-02-25 Last updated: 2018-03-19Bibliographically approved

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