uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Genome-wide association reveals that common genetic variation in the kallikrein-kinin system is associated with serum L-arginine levels.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. Dept. of Pharmacology, University of Oxford.
Show others and affiliations
2016 (English)In: Thrombosis and haemostasis, ISSN 2567-689X, Vol. 116, no 6, p. 1041-1049Article in journal (Refereed) Published
Abstract [en]

). Together these two loci explain 7 % of the total variance in serum L-arginine concentrations. The associations at both loci were replicated in independent cohorts with plasma L-arginine measurements (p<0.004). The two sentinel SNPs are in nearly complete LD with the nonsynonymous SNP rs3733402 at KLKB1 and the 5'-UTR SNP rs1801020 at F12, respectively. SNPs at both loci are associated with blood pressure. Our findings provide new insight into the genetic regulation of L-arginine and its potential relationship with cardiovascular risk.

Place, publisher, year, edition, pages
2016. Vol. 116, no 6, p. 1041-1049
Keywords [en]
Serum L-arginine concentration, coagulation, genome-wide association, kallikrein-kinin system
National Category
Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:uu:diva-343225DOI: 10.1160/TH16-02-0151PubMedID: 27656708OAI: oai:DiVA.org:uu-343225DiVA, id: diva2:1185746
Available from: 2018-02-26 Created: 2018-02-26 Last updated: 2018-02-26

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Authority records BETA

Jernerén, Fredrik

Search in DiVA

By author/editor
Jernerén, Fredrik
By organisation
Department of Pharmaceutical Biosciences
Pharmacology and Toxicology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 2 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf